In two recent papers, an international team of scientists describe the first known nitrogen-fixing organelle within a eukaryotic cell. The organelle is the fourth example in history of primary endosymbiosis—the process by which a prokaryotic cell is engulfed by a eukaryotic cell and evolves beyond symbiosis into an organelle. Read more »
ALS Work Using Tomography
Tomography allows 3D imaging of structures inside samples without the need to physically slice them open. A series of images is collected as a sample is rotated, and the raw data is computationally converted into digital sections that can be stacked to reconstruct 3D visualizations of the sample. The very high flux of x-rays and infrared light at the ALS allows collection of high-quality, high-speed 3D images at nanometer or micrometer resolution. Synchrotron tomography also enables photon-energy tuning for element- and chemistry-specific contrast, as well as phase-contrast imaging.
Tracking Platinum Movement on Fuel-Cell Electrodes
Researchers tracked the movement of the platinum nanoparticles that catalyze reactions in polymer electrolyte fuel cells (PEFCs) and correlated this movement with nanoparticle degradation. The results yielded solutions that can immediately reduce platinum waste in emission-free heavy-duty fuel-cell vehicles. Read more »
Why Do Batteries Sometimes Catch Fire and Explode?
In order to better understand how a resting battery might undergo thermal runaway after fast charging, scientists are using a technique called “operando x-ray microtomography” to measure changes in the state of charge at the particle level inside a lithium-ion battery after it’s been charged. Read more »
Internal Currents in Lithium Batteries after Fast Charging
In lithium batteries after fast charging, researchers measured the persistence of internal currents and found that large local currents continue even after charging has stopped. The work uses hard x-ray 3D imaging in a novel way and sheds light on the causes of thermal runaway and the catastrophic failure of lithium batteries at rest. Read more »
A Deep-Learning Analysis of Lithium-Plating Dynamics in Batteries
Lithium-metal solid-state batteries are a promising technology, but the deposition (plating) of lithium metal on electrode surfaces remains a significant technical hurdle. Here, researchers used micro-computed tomography data to train an artificial intelligence model to identify characteristics vital to improving battery performance. Read more »
A New Pathway for Clearing Misfolded Proteins
Researchers integrated several approaches, such as cryogenic 3D imaging at the ALS, to define a novel cellular pathway—involving a shared “garbage dump”—for clearing misfolded proteins from cells. The pathway is a potential therapy target for age-related diseases like Alzheimer’s, Huntington’s, and Parkinson’s diseases. Read more »
In Fruit-Fly Gut, Bacterial Niche Gets Remodeled for New Arrivals
Researchers found that fruit flies have a specialized niche in their digestive tracts that selects, maintains, and controls bacteria that benefit the fly. Colonization by one type of bacteria physically remodels the niche, promoting secondary colonization by unrelated bacteria. The results will help dissect the mechanisms of host-microbe symbiosis. Read more »
Structural organization of the spongy mesophyll
Many leaves have two layers of photosynthetic tissue: the palisade and spongy mesophyll. The latter is not well characterized and often treated as a random assemblage of irregularly shaped cells. These results show that simple principles may govern the organization and scaling of the spongy mesophyll in many plants and demonstrate the presence of structural patterns associated with leaf function. Read more »
Safely Studying Dangerous Infections Just Got a Lot Easier
Researchers have cranked up the speed of imaging infected cells using soft x-ray tomography, a technique that can generate incredibly detailed, three-dimensional scans. The approach gives an easy way to quickly examine how cells’ internal machinery responds to SARS-CoV-2, or other pathogens, as well as how the cells respond to drugs designed to treat the infection. Read more »
Rapid 3D Visualization of Lung Cells Altered by SARS-CoV-2
In this work, researchers illustrated the potential of soft x-ray tomography to rapidly characterize and quantify the structural changes induced in cells infected by SARS-CoV-2, revealing profound alterations of the subcellular architecture induced by viral infection over time. Read more »
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