The image depicts the complex formed between SARS-CoV-2 papain-like protease and human interferon-stimulated gene 15 protein. Small-angle scattering elucidated the structural details of this complex providing insight into its role in suppressing the innate immune response and also potential routes for development of therapeutics to combat COVID-19. Read more »
Key to Cleaner Combustion? Look to the Stars
Researchers made the first real-time, lab-based measurement of free radicals reacting under cosmic conditions, prompting elementary carbon and hydrogen atoms to coalesce into primal benzene rings. The findings are key to understanding how the universe evolved with the growth of carbon compounds and could also help the car industry make cleaner combustion engines. Read more »
Understanding the Hydrothermal Formation of NaNbO3: Its Full Reaction Scheme and Kinetics
To understand and tune the properties of hydrothermally produced NaNbO3, the reaction was studied in situ with powder x-ray diffraction, small-angle scattering, and total scattering with pair-distribution function analysis. The full reaction scheme and kinetics were revealed, showing two different temperature-dependent growth mechanisms. Read more »
Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor
van der Waals sphere representation of the factor VIII C1 domain, highlighting surface‐exposed hemophilia A–associated mutations that cause impaired von Willebrand factor binding and overlap with a pathogenic anti‐C1 domain inhibitor epitope. Read more »
Scientists Uncover a Different Facet of Fuel-Cell Chemistry
Solid oxide fuel cells are a promising technology for cleanly converting chemical energy to electrical energy. To improve the efficiency of these devices, researchers studied a model electrode material in a new way—by exposing a different facet of its crystal structure to oxygen gas at operating pressures and temperatures. Read more »
EPSCoR Collaboration Fosters New Research and New Careers
The DOE Established Program to Stimulate Competitive Research (DOE EPSCoR) encourages partnerships between national labs and researchers in qualifying states and territories. An EPSCoR collaboration with researchers from Kentucky has resulted in an ALS highlight, career advancement for young scientists, and a larger, center-scale proposal. Read more »
Artificial Spin Ice Toggles Twist in X-Ray Beams on Demand
ALS studies helped scientists understand how a nanoscale magnetic lattice (an artificial spin ice) acts as a toggle switch for x-ray beams with spiral character. The findings represent an important step toward the development of a versatile new tool for probing or controlling exotic phenomena in electronic and magnetic systems. Read more »
ALS in the News (May 2021)
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- Soft x-ray method promises nanocarrier breakthroughs for smart medicine
- New mineral named after ALS Senior Scientist Nobumichi Tamura
- How x-rays could make reliable, rapid COVID-19 tests a reality
- Channeling light into nanobelts
- Physical chemist Geri Richmond picked for top DOE science job
- Photons go to extremes
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Guiding Target Selection for COVID-19 Antibody Therapeutics
Protein-structure studies helped demonstrate that the primary target of antibody-based COVID-19 immunity is the part of the virus’s spike protein that can most easily mutate. The work anticipated the rise of SARS-CoV-2 variants and guides the selection of antibody therapeutics that are likely to be more resistant to immune escape. Read more »
Single-Domain Multiferroic Array-Addressable Terfenol-D (SMArT) Micromagnets for Programmable Single-Cell Capture and Release
Researchers develop programmable multiferroic micromotors that enable single-cell manipulation based on time-dependent functions of individual cells, such as cell secretion. Smart programmable multiferroic materials lay the groundwork for large-scale automated single-cell sorting and enable a broad spectrum of biotechnology applications. Read more »
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