Genetic Blueprint for the Bioproduction of an Antidepressant Drug Candidate December 2, 2019 - A set of genes from a marine bacterium has been found to encode the biosynthesis of a promising antidepressant drug candidate. This work, which used the ALS to solve the structure of a key enzyme, could enable industrial-scale bioproduction of the drug in ways that are more efficient and sustainable than chemical synthesis. Read more »
Crystal Misorientation Toughens Human Tooth Enamel November 27, 2019 - Researchers discovered that, in the nanoscale structure of human enamel (the hard outer layer of teeth), slight crystal misorientations serve as a natural toughening mechanism. The results help explain how human enamel can last a lifetime and provides insight into strategies for designing similarly tough bio-inspired synthetic materials. Read more »
Argon: Not So Noble in Earth’s Core November 27, 2019 - Researchers demonstrated the synthesis of a thermodynamically stable compound of argon and nickel at temperatures and pressures representative of the Earth’s core. The ability of argon, a noble gas, to react with other elements under these conditions may help solve outstanding geological questions, including the “missing argon paradox.” Read more »
A High-Pressure Compound of Argon and Nickel: Noble Gas in the Earth’s Core? November 21, 2019 - Researchers demonstrated the synthesis of a thermodynamically stable compound of Ar and Ni at thermodynamic conditions representative of the Earth's core. The results suggest that the abundance of Ar in the Earth's core is beyond a simple solubility of Ar in molten Ni–Fe but in chemical reactions in nature. Read more »
Machine Learning Helps Stabilize Synchrotron Light November 19, 2019 - Researchers showed that machine learning can predict noisy fluctuations in the size of beams generated by synchrotron light sources and correct them before they occur. The work solves a decades-old problem and will allow researchers to fully exploit the smaller beams made possible by recent advances in light source technology. Read more » 
Custom-Designed Models Reveal How Proteins Assemble on Minerals October 29, 2019 - Seashells, bone, and other hard tissues form through a little-understood process combining proteins and minerals. Researchers gained insight using a model system of proteins they designed and synthesized from scratch, characterizing how these building blocks assemble on mica. Read more »
Anomalous Orbital Structure in Two-Dimensional Materials October 28, 2019 - Researchers explored how structural distortions of the atomic lattice influence exotic electronic states in two-dimensional transition-metal dichalcogenides (TMDs). Polarization-dependent spectroscopy revealed an unexpectedly large crystal-field splitting of the valence electron states, a result of strong hybridization in metal–chalcogen orbitals. Read more »
Multimodal Study of Ion-Conducting Membranes October 25, 2019 - Using multiple x-ray characterization tools, researchers showed how chemical and structural changes improve the performance of a novel ion-conducting polymer (ionomer) membrane from 3M Company. The work provides insight into factors impacting the proton conductivity of ionomers used for fuel cells and the production of hydrogen fuel. Read more » 
Infrared Nanospectroscopy at Graphene–Liquid Interfaces October 21, 2019 - Researchers developed a new infrared approach to probing the first few molecular layers of a liquid in contact with a graphene electrode under operating conditions. The work offers a new way to study the interfaces that are key to understanding batteries, corrosion, and other bio- and electrochemical phenomena. Read more » 
ALS Confirms Mechanism for Improved Fuel Cell Catalysis September 24, 2019 - Aided by x-ray absorption spectroscopy at the ALS, researchers from Toyota and the University of Akron have uncovered a new catalysis mechanism to improve oxidation-reduction reactions in certain fuel cells by 40%. This enhancement, based on tin oxide, will support efforts to increase fuel efficiency in electric vehicles. Read more »