A set of genes from a marine bacterium has been found to encode the biosynthesis of a promising antidepressant drug candidate. This work, which used the ALS to solve the structure of a key enzyme, could enable industrial-scale bioproduction of the drug in ways that are more efficient and sustainable than chemical synthesis. Read more »
Science Briefs
Argon: Not So Noble in Earth’s Core
Researchers demonstrated the synthesis of a thermodynamically stable compound of argon and nickel at temperatures and pressures representative of the Earth’s core. The ability of argon, a noble gas, to react with other elements under these conditions may help solve outstanding geological questions, including the “missing argon paradox.” Read more »
Custom-Designed Models Reveal How Proteins Assemble on Minerals
Seashells, bone, and other hard tissues form through a little-understood process combining proteins and minerals. Researchers gained insight using a model system of proteins they designed and synthesized from scratch, characterizing how these building blocks assemble on mica. Read more »
Anomalous Orbital Structure in Two-Dimensional Materials
Researchers explored how structural distortions of the atomic lattice influence exotic electronic states in two-dimensional transition-metal dichalcogenides (TMDs). Polarization-dependent spectroscopy revealed an unexpectedly large crystal-field splitting of the valence electron states, a result of strong hybridization in metal–chalcogen orbitals. Read more »
Self-Assembling Nanomaterials Are Organized and Tunable
Perovskite superlattices have a wide variety of applications, but they are difficult to synthesize. Researchers have now characterized their self-assembly process to better understand how to create a variety of superlattice materials. Read more »
Multiple Levels of Chirality from Achiral Molecules
Liquid crystal samples were found to exhibit up to four levels of chirality, despite being made up of achiral molecules. The work sheds light on how molecular properties and competing interactions “propagate” order from the molecular level up to the microscale, leading to complexity similar to that found in biological materials. Read more »
Infrared Nano-Mapping of Local Strain in 2D Materials
Researchers have demonstrated an infrared technique to map and analyze strain in atomically thin crystals of hexagonal boron nitride (hBN) at the nanoscale. This ultrasensitive strain-imaging method could be a promising tool for the examination of low-dimensional materials of interest for electronic and photonic devices. Read more »
Fundamental Property of Arginine Revealed Through Solvation
Just 20 amino acids act as building blocks for all our proteins, but their chemical properties have been difficult to study at the most fundamental level. Combining experiments and theory at the ALS, researchers have now determined the ionization energy of arginine, an amino acid with over 100 isomers. Read more »
Molecular Framework Imparts Stability to Reactive Catalyst
Researchers have shown that a rigid metal–organic framework (MOF) can be used to stabilize core regions of a reactive catalyst that has potential for use in artificial photosynthesis. The framework immobilizes and preserves key reactive intermediates and affords a clearer view of how the catalyst’s structure correlates with function. Read more »
A Bullfrog’s Powerful Defense Against Toxic Red Tides
Working as a “molecular sponge,” a bullfrog protein known as saxiphilin provides powerful, yet little understood, protection against deadly neurotoxins produced in red tides. Crystallography studies at the ALS have clarified saxiphilin’s function, potentially enabling better ways to monitor and combat toxins in our oceans and food supplies. Read more »
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