The User Office is accepting new General User Proposals (GUPs) from scientists who wish to conduct research at the ALS in the 2020-2 (July–December) cycle. The deadline for submissions is March 4, 2020. Applicants are reminded that they may request joint access to the Molecular Foundry, a nanoscience user facility at Berkeley Lab, to support their ALS activities. Read more »
All News & Updates
The Choreography of Quantum Dot Fusion
X-ray scattering experiments helped reveal how nanosized crystals (“quantum dots”) self-assemble and fuse to form “supercrystals” with potentially useful electronic properties. The findings provide new insight into the fabrication of high-performance, low-cost electronic materials for photovoltaic and photon-sensing applications. Read more »
Milestone in Advanced Light Source Upgrade Project Will Bring in a New Ring
On Dec. 23, the ALS upgrade (ALS-U) project received CD-3a approval, which authorizes an important release of funds for purchasing equipment and formally approves the start of construction on the accumulator ring. Read more »
Unique Cancer Drug Discovered With Help From Advanced Light Source Begins Historic Clinical Trial
Errors in the KRAS gene, which encodes a crucial cell-signaling protein, are one of the most common causes of cancer. Seeking to develop a long-sought direct inhibitor, researchers at Amgen conducted x-ray crystallography of KRAS(G12C) proteins at the ALS. The high-resolution structural maps helped Amgen make the breakthrough discovery of a small pocket on the molecule. Read more »
Freeze Frame: Scientists Capture Atomic-Scale Snapshots of Artificial Proteins
Protein-like molecules called polypeptoids have great promise as precision building blocks for creating a variety of designer nanomaterials. In this study, rsearchers used cryo-EM, a technique originally designed to image proteins in solution, as well as x-ray scattering techniques, to characterize the structure of polypeptide nanosheets. Read more »
Welcome to the 2019–2020 ALS Fellows
This November, we welcomed the new doctoral fellows to the Advanced Light Source in an orientation event. ALS Deputy for Science Andreas Scholl hosted the event and invited guests from around the ALS and Berkeley Lab to give an overview of the resources our fellows will have. Read more »
Heidi Clark, ALS Senior Administrator Supervisor
After nine years in the Intellectual Property Office, Heidi Clark joined the ALS two months ago. Keep reading to find out what skills and secret talents she’s brought from previous jobs and just what “ham mode” means. Read more »
Genetic Blueprint for the Bioproduction of an Antidepressant Drug Candidate
A set of genes from a marine bacterium has been found to encode the biosynthesis of a promising antidepressant drug candidate. This work, which used the ALS to solve the structure of a key enzyme, could enable industrial-scale bioproduction of the drug in ways that are more efficient and sustainable than chemical synthesis. Read more »
Crystal Misorientation Toughens Human Tooth Enamel
Researchers discovered that, in the nanoscale structure of human enamel (the hard outer layer of teeth), slight crystal misorientations serve as a natural toughening mechanism. The results help explain how human enamel can last a lifetime and provides insight into strategies for designing similarly tough bio-inspired synthetic materials. Read more »
Argon: Not So Noble in Earth’s Core
Researchers demonstrated the synthesis of a thermodynamically stable compound of argon and nickel at temperatures and pressures representative of the Earth’s core. The ability of argon, a noble gas, to react with other elements under these conditions may help solve outstanding geological questions, including the “missing argon paradox.” Read more »
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