The evolving oxygen state plays key roles in the performance and stability of high-energy batteries involving oxygen redox reactions. Comparison of the mRIXS profiles of four different oxygen states reveals that oxygen redox states in batteries have distinct widths and positions along the excitation energy. Read more »
Journal Covers
Blending Ionic and Coordinate Bonds in Hybrid Semiconductor Materials: A General Approach toward Robust and Solution-Processable Covalent/Coordinate Network Structures
Blending ionic and coordinate bonds in copper iodide based hybrid semiconductor materials with extended covalent/coordinate network structures leads to greatly enhanced solubility and solution processability, making it possible to form high-quality films for device fabrication. Read more »
X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance
The M2 proton channel, shown with front and back monomer helices removed, is an anti-influenza drug target. Here, a bound inhibitor blocks the transport of protons through the V27A mutant channel. Read more »
Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY
Finding OG and avoiding G: DNA repair enzyme MutY distinguishes between undamaged guanine (green) and oxidized guanine when targeting OG:A mispairs. A structural motif within the C-terminal domain (violet) responds to OG to G substitution and appears mechanistically coupled to the adenine removal site (gray) in the N-terminal domain (cyan). Read more »
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
KRASG12C has emerged as a promising target in the treatment of solid tumors; however, clinically viable inhibitors have yet to be identified. Here, researchers report on structure-based design and optimization efforts, culminating in the identification of AMG 510, a highly potent, selective, and well-tolerated KRASG12C inhibitor currently in phase I clinical trials (NCT03600883). Read more »
A High-Pressure Compound of Argon and Nickel: Noble Gas in the Earth’s Core?
Researchers demonstrated the synthesis of a thermodynamically stable compound of Ar and Ni at thermodynamic conditions representative of the Earth’s core. The results suggest that the abundance of Ar in the Earth’s core is beyond a simple solubility of Ar in molten Ni–Fe but in chemical reactions in nature. Read more »
Chemical and Morphological Origins of Improved Ion Conductivity in Perfluoro Ionene Chain Extended Ionomers
Resonant x-ray scattering and x-ray absorption spectroscopy with elemental sensitivity unravel structural features tied to water–ion domains and discern sulfur-containing groups in sulfonated ionomers, which help delineate chemical factors controlling their phase-separated morphology and governing ion transport. Read more »
Sulfur-linked cyanobiphenyl-based liquid crystal dimers and the twist-bend nematic phase
The synthesis and characterization of cyanobiphenyl-based liquid crystal dimers containing sulfur links between the spacer and mesogenic units are described. Resonant x-ray scattering studies of the twist-bend nematic phase at both the carbon and sulfur absorption edges were performed to determine the critical behaviour of the helical pitch at the transition to the nematic phase. Read more »
Shape transformation and self-alignment of Fe-based nanoparticles
Magnetic nanoparticles (MNPs) have widespread applications in biotechnology, materials science, engineering, and environmental studies. Thus, much attention has been paid to their controllable synthesis. Three new functions of iron-based nanoparticles are reported: shape transformation, oxidation prevention, and self-alignment. Read more »
The Stomatopod Telson: Convergent Evolution in the Development of a Biological Shield
In this article, researchers identify multiscale structure‐mechanical property relationships within the shield-like exoskeletal telson structure of the mantis shrimp, used for defense and protection. Comparison of telsons from two evolutionarily divergent species reveal differences in macromorphology, cuticle thickness, and mineralization, imparting compressive stiffness as well as compliance for energy absorption. Read more »
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