Blending ionic and coordinate bonds in copper iodide based hybrid semiconductor materials with extended covalent/coordinate network structures leads to greatly enhanced solubility and solution processability, making it possible to form high-quality films for device fabrication. Read more »
Journal Covers
X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance
The M2 proton channel, shown with front and back monomer helices removed, is an anti-influenza drug target. Here, a bound inhibitor blocks the transport of protons through the V27A mutant channel. Read more »
Highly Permeable Perfluorinated Sulfonic Acid Ionomers for Improved Electrochemical Devices: Insights into Structure-Property Relationships
Perfluorinated sulfonic acid ionomers (PFSAs) induce significant mass-transport limitations in proton exchange membrane fuel cell catalyst layers due to their semicrystalline PTFE-based matrix. We present a novel PFSA with an amorphous perfluorinated matrix, which vastly improves gas permeability, reduces transport resistance, and improves catalyst utilization in functional catalyst layers. Read more »
77Se NMR Probes the Protein Environment of Selenomethionine
Sulfur is critical for protein structure and function but lacks a sensitive isotope for nuclear magnetic resonance (NMR) experiments. This can be circumvented by substituting sulfur with selenium, which has an NMR-compatible isotope (77Se). To enable interpretation of the NMR data, the structures of five of protein variants were solved by x-ray crystallography to a resolution of 1.2 Å. Read more »
Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY
Finding OG and avoiding G: DNA repair enzyme MutY distinguishes between undamaged guanine (green) and oxidized guanine when targeting OG:A mispairs. A structural motif within the C-terminal domain (violet) responds to OG to G substitution and appears mechanistically coupled to the adenine removal site (gray) in the N-terminal domain (cyan). Read more »
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
KRASG12C has emerged as a promising target in the treatment of solid tumors; however, clinically viable inhibitors have yet to be identified. Here, researchers report on structure-based design and optimization efforts, culminating in the identification of AMG 510, a highly potent, selective, and well-tolerated KRASG12C inhibitor currently in phase I clinical trials (NCT03600883). Read more »
A High-Pressure Compound of Argon and Nickel: Noble Gas in the Earth’s Core?
Researchers demonstrated the synthesis of a thermodynamically stable compound of Ar and Ni at thermodynamic conditions representative of the Earth’s core. The results suggest that the abundance of Ar in the Earth’s core is beyond a simple solubility of Ar in molten Ni–Fe but in chemical reactions in nature. Read more »
Chemical and Morphological Origins of Improved Ion Conductivity in Perfluoro Ionene Chain Extended Ionomers
Resonant x-ray scattering and x-ray absorption spectroscopy with elemental sensitivity unravel structural features tied to water–ion domains and discern sulfur-containing groups in sulfonated ionomers, which help delineate chemical factors controlling their phase-separated morphology and governing ion transport. Read more »
Sulfur-linked cyanobiphenyl-based liquid crystal dimers and the twist-bend nematic phase
The synthesis and characterization of cyanobiphenyl-based liquid crystal dimers containing sulfur links between the spacer and mesogenic units are described. Resonant x-ray scattering studies of the twist-bend nematic phase at both the carbon and sulfur absorption edges were performed to determine the critical behaviour of the helical pitch at the transition to the nematic phase. Read more »
Shape transformation and self-alignment of Fe-based nanoparticles
Magnetic nanoparticles (MNPs) have widespread applications in biotechnology, materials science, engineering, and environmental studies. Thus, much attention has been paid to their controllable synthesis. Three new functions of iron-based nanoparticles are reported: shape transformation, oxidation prevention, and self-alignment. Read more »
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