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- First detailed electronic study of new nickelate superconductor
- Influential electrons? Physicists uncover a quantum relationship
- Jennifer Doudna awarded 2020 Wolf Prize in Medicine
- New discovery makes it easier to design synthetic proteins that rival their natural counterparts
- Milestone in Advanced Light Source Upgrade Project will bring in a new ring
- The superpowers of super-thin materials
- Unique cancer drug discovered with help from Advanced Light Source begins historic clinical trial
- Scientists discover how proteins form crystals that tile a microbe’s shell
- MIT researchers realize “ideal” kagome metal electronic structure
- Freeze frame: Scientists capture atomic-scale snapshots of artificial proteins
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The Choreography of Quantum Dot Fusion
X-ray scattering experiments helped reveal how nanosized crystals (“quantum dots”) self-assemble and fuse to form “supercrystals” with potentially useful electronic properties. The findings provide new insight into the fabrication of high-performance, low-cost electronic materials for photovoltaic and photon-sensing applications. Read more »
Milestone in Advanced Light Source Upgrade Project Will Bring in a New Ring
On Dec. 23, the ALS upgrade (ALS-U) project received CD-3a approval, which authorizes an important release of funds for purchasing equipment and formally approves the start of construction on the accumulator ring. Read more »
Unique Cancer Drug Discovered With Help From Advanced Light Source Begins Historic Clinical Trial
Errors in the KRAS gene, which encodes a crucial cell-signaling protein, are one of the most common causes of cancer. Seeking to develop a long-sought direct inhibitor, researchers at Amgen conducted x-ray crystallography of KRAS(G12C) proteins at the ALS. The high-resolution structural maps helped Amgen make the breakthrough discovery of a small pocket on the molecule. Read more »
Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY
Finding OG and avoiding G: DNA repair enzyme MutY distinguishes between undamaged guanine (green) and oxidized guanine when targeting OG:A mispairs. A structural motif within the C-terminal domain (violet) responds to OG to G substitution and appears mechanistically coupled to the adenine removal site (gray) in the N-terminal domain (cyan). Read more »
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
KRASG12C has emerged as a promising target in the treatment of solid tumors; however, clinically viable inhibitors have yet to be identified. Here, researchers report on structure-based design and optimization efforts, culminating in the identification of AMG 510, a highly potent, selective, and well-tolerated KRASG12C inhibitor currently in phase I clinical trials (NCT03600883). Read more »
Freeze Frame: Scientists Capture Atomic-Scale Snapshots of Artificial Proteins
Protein-like molecules called polypeptoids have great promise as precision building blocks for creating a variety of designer nanomaterials. In this study, rsearchers used cryo-EM, a technique originally designed to image proteins in solution, as well as x-ray scattering techniques, to characterize the structure of polypeptide nanosheets. Read more »
ALS in the News (December 2019)
- Six Berkeley Lab scientists named AAAS Fellows
- Berkeley Lab names Robert Kostecki director of the Energy Storage and Distributed Resources Division
- New material captures and converts toxic air pollutant into industrial chemical
- The beauty of imperfections: Linking atomic defects to 2D materials’ electronic properties
- Mechanisms of soft tissue and protein preservation in Tyrannosaurus rex
- Scientists explore Egyptian mummy bones with x-rays and infrared light to gain new insight on ancient life
- New understanding of antibiotic synthesis
- Go with the flow: Scientists design better batteries for a renewable energy grid
- Cage molecules act as molecular sieves for hydrogen isotope separation
- Graphene in the making
- Jennifer Doudna honored with two prizes
Genetic Blueprint for the Bioproduction of an Antidepressant Drug Candidate
A set of genes from a marine bacterium has been found to encode the biosynthesis of a promising antidepressant drug candidate. This work, which used the ALS to solve the structure of a key enzyme, could enable industrial-scale bioproduction of the drug in ways that are more efficient and sustainable than chemical synthesis. Read more »
Crystal Misorientation Toughens Human Tooth Enamel
Researchers discovered that, in the nanoscale structure of human enamel (the hard outer layer of teeth), slight crystal misorientations serve as a natural toughening mechanism. The results help explain how human enamel can last a lifetime and provides insight into strategies for designing similarly tough bio-inspired synthetic materials. Read more »
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