Researchers found a way to turn single-use plastics (e.g., grocery bags and packaging) into useful liquid fuels, like components of gasoline or diesel, without needing high heat, rare metals, or added chemicals. The work presents a promising pathway to address the global plastic waste crisis, with both environmental and economic advantages. Read more »
Vertical gradient in atmospheric particle phase state: a case study over the alaskan arctic oil fields
Integrating chemical composition and phase state measurements demonstrated that carbonaceous-rich and organic-dominated particles exhibited higher viscosities, while inorganic-rich particles displayed lower viscosities. This finding establishes an association between composition and phase state, offering critical insights into the vertical stratification of Arctic particles. Read more »
Identification of Structurally Novel KRASG12C Inhibitors through Covalent DNA-Encoded Library Screening
DNA-encoded library (DEL) technology was used to prepare a ~1.6 × 107-compound cysteine-reactive library (representative component shown at bottom, cysteine-reactive site indicated). Screening this library against the KRASG12C oncoprotein identified multiple structurally novel inhibitors of this challenging-to-drug target (e.g., frontmost green compound in the X-ray structure at right, covalent bond to KRASG12C indicated). Read more »
Operando Unveiling of Hydrogen Spillover Mechanisms on Tungsten Oxide Surfaces
An artistic depiction of hydrogen spillover on Pt/WO3, illustrating H2 activation and dissociation on Pt metal clusters, followed by hydrogen migration to WO3 for water formation. At elevated temperatures, water desorption and surface-to-bulk diffusion of hydrogen drive tungsten redox and oxygen vacancy formation on the surface of WO3. Read more »
Structure of the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins
The study reports the first structure of human EPG5 (HsEPG5) determined by cryo-EM and AlphaFold2 modeling. Read more »