Last year, drug discovery company Plexxikon made front-page news with its highly successful anti-cancer drug, Zelboraf, a product that was chemically optimized using data from ALS x-rays. Designed to disrupt malignant melanoma, the drug was so successful in human testing that trials were halted so that patients in the trial could all be given Zelboraf. Zelboraf marked a significant advancement for patients with metastatic melanoma who historically have had very limited treatment options.
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All News & Updates
Wine, Water, and X-Ray Tomography
ALS user Andrew McElrone’s research on grapevine rootstock water transport physiology is key to the future of California’s grape-growing industry. The plant biologist’s ultimate goal is to develop sustainable water use strategies for growers, giving them hard data about how much drought their plants can sustain and which species are ideal for an agricultural future with an uncertain water supply.
Corie Ralston: New Head of Berkeley Center for Structural Biology…and Award-Winning Writer
Corie Ralston’s appointment as Head of the Berkeley Center for Structural Biology (BCSB) has her busy looking at budgets, funding, and big-picture goals. The biophysicist staff scientist has been with BCSB for more than 10 years, so much of what she’s considering comes from an intimate familiarity with the day-to-day operations and challenges of theRead More Read more »
Direct Kinetic Measurements of a Criegee Intermediate
“Criegee intermediates” are elusive molecules that play a pivotal role in atmospheric chemistry and are also byproducts of key combustion reactions. At the Chemical Dynamics Beamline, the reaction rates of one form of Criegee intermediate was directly measured for the first time, with some surprising results. Read more »
Two Novel Ultra-Incompressible Materials
Materials that are mechanically, thermally, and chemically stable at extreme conditions are valuable for aerospace engineering and fission/fusion research. Researchers have synthesized and characterized two such materials: Re2N and Re3N are both extremely incompressible. Read more »
ALS Reveals New State of Matter
ALS user groups from Princeton and Stanford have been making waves this past year with several high-profile papers and extensive news coverage of their work on a new state of matter embodied by so-called “topological insulators,” materials that conduct electricity only on their surfaces. Read more »
Molecular Measurements of the Deep-Sea Oil Plume in the Gulf of Mexico
To study the effects of oil spilled from the Deepwater Horizon blowout, researchers collected deep-water samples from across the Gulf of Mexico and analyzied their physical, chemical, and microbiological properties using a variety of techniques, including SR-FTIR. Read more »
Platinum Nanoclusters Out-Perform Single Crystals
Researchers have found that under high pressure—comparable to the pressures at which many industrial technologies operate—platinum surfaces can change their structure dramatically in response to the presence of high-coverage reactants. Read more »
Real-Time Chemical Imaging of Bacterial Biofilm Development
Almost all bacteria can form biofilms—dynamic communities of cells enclosed in self-produced matrices of polymers. Researchers have developed a robust and label-free method to probe the chemical underpinnings of developing bacterial biofilms. Read more »
Mechanical Behavior of Indium Nanostructures
Indium is a key material in lead-free solder applications for microelectronics due to its excellent wetting properties, extended ductility, and high electrical conductivity. Researchers have investigated the small-scale mechanics of indium nanostructures. Read more » 