Researchers used soft x-ray tomography to gain a 3D whole-cell view of how insulin-producing pancreatic cells react upon exposure to glucose and a diabetes drug. The approach enables direct quantification of intracellular responses before, during, and after cell stimulation, providing new insights into how drugs alter cell function. Read more »
All News & Updates
Probing Composite Materials to Make Better Batteries
Researchers found that when an ion-conducting polymer composite is placed in an electric field, it forms ion-rich hotspots that continue to grow for hours after the field is removed. The study opens a new path to understanding the dynamic structure of composite materials for smaller, lighter batteries. Read more »
Construction, characterization and crystal structure of a fluorescent single-chain Fv chimera
In vitro display technologies based on phage and yeast have a successful history of selecting single-chain variable fragment (scFv) antibodies against various targets. However, single-chain antibodies are often unstable and poorly expressed. We explore the feasibility of converting scFv antibodies to an intrinsically fluorescent format by inserting a monomeric, stable fluorescent protein between the light- and heavy-chain variable regions. Read more »
Actor in a Supporting Role: Substrate Effects on 2D Layers
ALS studies highlighted interactions that can occur between technologically intriguing 2D materials and the substrates that physically support them. The results provide important insights into the issue of non-negligible interlayer coupling and demonstrate the potential for tuning single-layer properties through substrate engineering. Read more »
March 3 Deadline for General User Proposals
The User Office is accepting new General User Proposals (GUPs) from scientists who wish to conduct research at the ALS in the 2021-2 (August–December) cycle. The deadline for submissions is March 3, 2021. Applicants are reminded that they may request joint access to the Molecular Foundry, a nanoscience user facility at Berkeley Lab, to support their ALS activities. Read more »
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells
A number of clinically validated drugs have been developed by repurposing the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex with molecular glue degraders to eliminate disease-driving proteins. Here, we present the identification of a first-in-class GSPT1-selective cereblon E3 ligase modulator, CC-90009, that targets acute myeloid leukemia blasts and leukemia stem cells. Read more »
A Detailed Look Inside Tsetse Flies
To better understand the unique reproductive biology of tsetse flies, which are carriers of the parasites that cause a deadly infection known as African sleeping sickness, researchers explored the intact organs and tissues of tsetse flies using a powerful 3D x-ray imaging technique at Berkeley Lab’s Advanced Light Source. Read more »
Identifying Ionic and Electronic Charge Transfer at Oxide Heterointerfaces
Researchers identified how ion and electron transfer naturally balance at the LaAlO3/SrTiO3 oxide heterointerface, affecting the band alignment and magnetic signature of the interface. The results show that Sr ions are more mobile at the interface than in the bulk, implicating a high importance of ionic charge transfer in oxide heterostructures. Read more »
Materials from Town Hall on Shutdown Schedules Now Available
On January 26, the ALS held a town hall on the schedule for upcoming long shutdowns. The event provided up-to-date information on the schedule, explained the motivations behind decisions, and discussed principles and strategies for future decision-making. Slides and a recording from the event, as well as an FAQs document, are posted to the ALS website. Read more »
2021 Update from ALS Director Steve Kevan
Steve Kevan reflects on the resilience of the ALS community over the past year and the progress we’ve continued to make, from timely COVID research to remote access on a variety of beamlines. As we look to the future, the continued efforts of the whole team will set us up for impactful science during and after the ALS Upgrade Project. Read more »
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