Finding OG and avoiding G: DNA repair enzyme MutY distinguishes between undamaged guanine (green) and oxidized guanine when targeting OG:A mispairs. A structural motif within the C-terminal domain (violet) responds to OG to G substitution and appears mechanistically coupled to the adenine removal site (gray) in the N-terminal domain (cyan). Read more »
All News & Updates
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
KRASG12C has emerged as a promising target in the treatment of solid tumors; however, clinically viable inhibitors have yet to be identified. Here, researchers report on structure-based design and optimization efforts, culminating in the identification of AMG 510, a highly potent, selective, and well-tolerated KRASG12C inhibitor currently in phase I clinical trials (NCT03600883). Read more »
Freeze Frame: Scientists Capture Atomic-Scale Snapshots of Artificial Proteins
Protein-like molecules called polypeptoids have great promise as precision building blocks for creating a variety of designer nanomaterials. In this study, rsearchers used cryo-EM, a technique originally designed to image proteins in solution, as well as x-ray scattering techniques, to characterize the structure of polypeptide nanosheets. Read more »
Welcome to the 2019–2020 ALS Fellows
This November, we welcomed the new doctoral fellows to the Advanced Light Source in an orientation event. ALS Deputy for Science Andreas Scholl hosted the event and invited guests from around the ALS and Berkeley Lab to give an overview of the resources our fellows will have. Read more »
Heidi Clark, ALS Senior Administrator Supervisor
After nine years in the Intellectual Property Office, Heidi Clark joined the ALS two months ago. Keep reading to find out what skills and secret talents she’s brought from previous jobs and just what “ham mode” means. Read more »
Genetic Blueprint for the Bioproduction of an Antidepressant Drug Candidate
A set of genes from a marine bacterium has been found to encode the biosynthesis of a promising antidepressant drug candidate. This work, which used the ALS to solve the structure of a key enzyme, could enable industrial-scale bioproduction of the drug in ways that are more efficient and sustainable than chemical synthesis. Read more »
Crystal Misorientation Toughens Human Tooth Enamel
Researchers discovered that, in the nanoscale structure of human enamel (the hard outer layer of teeth), slight crystal misorientations serve as a natural toughening mechanism. The results help explain how human enamel can last a lifetime and provides insight into strategies for designing similarly tough bio-inspired synthetic materials. Read more »
Argon: Not So Noble in Earth’s Core
Researchers demonstrated the synthesis of a thermodynamically stable compound of argon and nickel at temperatures and pressures representative of the Earth’s core. The ability of argon, a noble gas, to react with other elements under these conditions may help solve outstanding geological questions, including the “missing argon paradox.” Read more »
Tony Warwick Receives Director’s Award
Tony Warwick was recognized for outstanding service in the area of x-ray optics and beamline design in support of the mission of Berkeley Lab’s Advanced Light Source. Read more »
Call for 2017 to 2019 Publications
Our next Department of Energy triennial review is coming up soon. Please help ensure our records include all publications resulting from work done, in whole or in part, at the Advanced Light Source (ALS), especially those published in 2017 to 2019. Read more »
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