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Targeting Bacteria That Cause Meningitis and Sepsis

Researchers determined the structure of a human antibody that broadly protects against a bacterium that causes meningitis and sepsis. The work provides molecular-level information about how the antibody confers broad immunity against a variable target and suggests strategies for further improvement of available vaccines. Read more »PPT-icon-35 PDF-icon-35

2018 ALS User Meeting Highlights

Past, present, and future converged at the 2018 ALS User Meeting, where attendees celebrated the 25th anniversary of first light and CD-1 approval of the ALS Upgrade project. Planned with the next generation of users in mind, this year’s meeting emphasized tutorials on a wide variety of ALS techniques for both new and seasoned users. Read more »

Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei

Recent super-resolution fluorescence microscopy studies have revealed significantly altered nuclear organization between normal lymphocyte nuclei and those of classical Hodgkin’s lymphoma. Reported here are the first near-field IR imaging of lymphocyte nuclei, and far-field IR imaging results of whole lymphocytes and nuclei from normal human blood. Read more »

Unwinding a Quadruple Helix

The double helix is not the only structure formed by DNA and RNA. Guanine-rich DNA and RNA sequences can fold into quadruple-helix structures called G-quadruplexes. Recently, researchers visualized the unfolding of a G-quadruplex by a protein called DHX36, gaining valuable insight into a potential target for drug development. Read more »

Miscibility–Function Relations in Organic Solar Cells: Significance of Optimal Miscibility in Relation to Percolation

In this article, Ye et al. present the determination of liquidus miscibility and its temperature dependence of organic films by scanning transmission x‐ray microscopy and outline an approach to convert liquidus miscibility to an effective Flory‐Huggins interaction parameter χ, which will pave a way to predict morphology and processing strategies of polymer solar cells. Read more »

ALS-U Project Receives CD-1 Approval

The ALS Upgrade (ALS-U) project has received federal approval (CD-1) to proceed with preliminary design, planning, and R&D work. This major upgrade will boost the brightness and coherent flux of ALS soft x-ray beams at least a hundredfold, enabling transformative science that cannot be performed on any existing or planned light source in the world. Read more »

Mike Martin and Hendrik Ohldag Named 2018 APS Fellows

Two ALS scientists have been named Fellows of the American Physical Society. Mike Martin, a senior scientist and operations lead for the Photon Science Group is recognized “for the advancement of synchrotron infrared spectroscopy including the development of synchrotron infrared nanospectroscopy and 3D FTIR tomography.” Hendrik Ohldag, a staff scientist who joined the ALS earlier this month, is recognized “for contributions to unique insight into complex magnetic materials with unprecedented spatial and temporal resolution using novel x-ray techniques.” Read more »

Final Registration Reminder for the ALS User Meeting, October 2-4

Online registration for this year’s User Meeting closes Thursday, September 27. This year’s event features an exciting new format designed especially with students and early career scientists in mind. We will also celebrate the ALS’s 25th anniversary with retrospective talks about how the ALS was built and how our science has evolved over time. Read more »