While the SHP2 protein helps regulate cellular activity, mutations in its structure can lead to cancer. X-ray crystallography at the ALS and SSRL has revealed differences between normal and mutated SHP2, as well as how it binds to certain cancer drugs. These structural insights open the door to new types of cancer therapy. Read more »
Science Briefs
Palladium and Zirconium Convert Greenhouse Gases into Fuel
Greenhouse gases cause the rising global temperatures associated with climate change. At the ALS, researchers have determined that palladium/zirconium catalysts can reduce greenhouse gases like methane and carbon dioxide by converting them into useful fuel. Read more »
Tunable Ferromagnetism in a 2D Material at Room Temperature
Researchers combined soft x-ray spectroscopy and microscopy to demonstrate the tunable ferromagnetic characteristics of a two-dimensional layered material at room temperature. The results open up exciting opportunities for the use of such materials in low-power spintronics, high-density magnetic storage, and flexible electronics. Read more »
Antibody Therapy for Autoimmune Diseases
The balance between two types of white blood cells is disrupted in autoimmune diseases. Using protein crystallography, scientists have identified a human antibody that locks interleukin-2, a signaling protein, in a conformation that preferentially activates one cell type to restore the balance and treat autoimmune diseases. Read more »
Unwinding a Quadruple Helix
The double helix is not the only structure formed by DNA and RNA. Guanine-rich DNA and RNA sequences can fold into quadruple-helix structures called G-quadruplexes. Recently, researchers visualized the unfolding of a G-quadruplex by a protein called DHX36, gaining valuable insight into a potential target for drug development. Read more »
Ordered Magnetic Patterns in a Disordered Magnetic Material
Scientists have confirmed the presence of chirality, or handedness, in nanometers-thick samples of amorphous (noncrystalline) multilayer materials. The chirality—which potentially could be exploited to transmit and store data in a new way—was observed in the domain walls between neighboring regions of opposite spin. Read more »
Nanoscale Characterization of Iron and Calcium in the Alzheimer’s Brain
The amyloid plaques that accumulate in Alzheimer’s disease contain stores of iron. Using scanning transmission x-ray microscopy, researchers have characterized the iron’s chemical states in unprecedented detail. Their nanoscale analysis revealed excessive chemical reduction of the iron, which can release damaging free radicals. Read more »
New Manganese Materials Bolster Cathode Capacity
The most expensive component of a battery, the cathode, requires rare transition metals like cobalt. Previous attempts to replace cobalt with inexpensive and non-toxic manganese delivered insufficient performance. Now, researchers have optimized the composition of high-energy-density, high-capacity manganese-based cathodes. Read more »
Oxygen Vacancies Matter in the LaNiO3 Metal–Insulator Transition
Electronic structure measurements using x-ray absorption spectroscopy suggest that oxygen vacancies contribute to the metal–insulator transition in ultrathin films of LaNiO3. The results give scientists another “knob” to turn to tune this important transition, which could be useful for making advanced electronic devices. Read more »
Open and Shut: Pain Signals in Nerve Cells
Researchers used x-ray data to define the structure of a closed protein gate important for neuronal signaling. Comparing the closed gate with previously known structures of the same gate when open, researchers now have a comprehensive picture of proton-dependent channels in neurons. Read more »
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