Scanning transmission x-ray microscopy at the ALS’s COSMIC beamline contributed to a battery study that used an innovative approach to machine learning to speed up the learning curve about a process that shortens the life of fast-charging lithium batteries. It represents the first time this brand of “scientific machine learning” was applied to battery cycling. Read more »
ALS Work Using Microscopy/Imaging
These techniques use the light-source beam to obtain pictures with fine spatial resolution of the samples under study and are used in diverse research areas such as cell biology, lithography, infrared microscopy, radiology, and x-ray tomography.
Coral Skeleton Reveals Hidden Structures under Multimodal Scrutiny
A powerful new microscope combining ptychography with x-ray linear dichroism provides nanoscale insight into the biomineral strength and resilience of a coral skeleton. The technique’s previously unachievable spatial resolution and contrast will open up new lines of research for users of x-ray microscopy at the ALS. Read more »
Skyrmion Creation and Annihilation Made Simple
Researchers developed a simple approach to writing and deleting skyrmions on demand, using heat and magnetic fields generated by an electrical current, by-products normally considered problematic. The ubiquitous character of these effects, coupled with simplicity of design, offers much-needed scalability and broad applicability. Read more »
A COSMIC Approach to Nanoscale Science
COSMIC, a multipurpose x-ray instrument, has made headway since its launch less than two years ago, with groundbreaking contributions in fields ranging from batteries to biominerals. Its capabilities include world-leading microscopy resolution, extreme chemical sensitivity, and ultrafast scanning speed. Read more »
To Speed Discovery, Infrared Microscopy Goes “Off the Grid”
Researchers developed a highly efficient way to collect infrared microscopy data that avoids the use of slow, grid-based raster scans. The method substantially reduces image-acquisition times by autonomously increasing sampling density in regions of interest, facilitating infrared spectromicroscopy of biochemical processes in real time. Read more »
3D Whole-Cell Mapping of Insulin Secretion
Researchers used soft x-ray tomography to gain a 3D whole-cell view of how insulin-producing pancreatic cells react upon exposure to glucose and a diabetes drug. The approach enables direct quantification of intracellular responses before, during, and after cell stimulation, providing new insights into how drugs alter cell function. Read more »
A Detailed Look Inside Tsetse Flies
To better understand the unique reproductive biology of tsetse flies, which are carriers of the parasites that cause a deadly infection known as African sleeping sickness, researchers explored the intact organs and tissues of tsetse flies using a powerful 3D x-ray imaging technique at Berkeley Lab’s Advanced Light Source. Read more »
2D MXene Shows Evidence of a Magnetic Transition
A variety of experiments, including ALS x-ray studies, provided direct evidence of a magnetic transition in a 2D compound called a MXene (pronounced “maxene”). The finding adds new functionality to a family of materials with numerous ways to fine-tune properties for applications ranging from spintronic devices to electromagnetic shielding. Read more »
Xylella fastidiosa causes transcriptional shifts that precede tylose formation and starch depletion in xylem
During Pierce’s disease, Xylella fastidiosa triggers transcriptional changes in grapevines and induces major physiological responses, including tylose formation and starch depletion. X-ray computed microtomography and a machine-learning algorithm were used to track the depletion of starch reserves in the xylem of a grapevine stem infected with Pierce’s disease. Read more »
Unique X-Ray Microscope Reveals Dazzling 3D Cell Images
Researchers used soft x-ray tomography to reveal never-before-seen details about insulin secretion in pancreatic cells taken from rats. By quantifying subcellular rearrangements in response to drugs, the results are an important first step for bridging the longstanding gap between structural biology and physiology. Read more »
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