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Programmable Micromagnets for Single-Cell Sorting

Researchers demonstrated that electrically induced mechanical strain can control the magnetic state of tiny magnets used to sort biological cells. The work lays the foundation for a programmable, single-cell sorting platform to support a wide variety of biotechnology applications, including personalized cancer treatments. Read more »PPT-icon-35 PDF-icon-35

How X-Rays Could Make Reliable, Rapid COVID-19 Tests a Reality

A highly sensitive lateral flow assay—the same type of device used in home pregnancy tests—could be developed using pairs of rigid antibodies that bind to the SARS-CoV-2 nucleocapsid protein. SAXS data showed that a particular pair of monoclonal antibodies bound to the nucleocapsid protein very strongly and stably, in part due to the antibodies’ rigidity. Read more »

New Tools Link Catalytic Activity to Nanoscale Transformations

Transitioning to a clean hydrogen economy will require cheaper, more efficient ways to split water molecules. To address bottlenecks in the water-splitting process, researchers developed a suite of advanced tools, including a liquid flow cell that enables electrochemical studies of catalysts under working conditions. Read more »

High-Efficiency Organic Photovoltaics using Eutectic Acceptor Fibrils to Achieve Current Amplification

Researchers report the fabrication of ternary organic solar cells, achieving a significant JSC boost, by virtue of their optimized crystalline feature, with the formation of eutectic crystalline fibrils. The optimal morphology suppresses energetic disorder and nongeminate recombination, and increases charge transfer and transport, yielding a high efficiency of 17.84% with significant current amplification. Read more »

Graphene Outperforms Metal Junctions for 2D Semiconductors

Researchers found that graphene performs ten times better than metal in transmitting a photoinduced current across interfaces with 2D semiconductors. Nanoscale-resolution band-structure measurements provided a deeper understanding of charge transport in these systems and will help in engineering more efficient contacts. Read more »

A Properly Tailored Tail Boosts Solar-Cell Efficiency

With the help of structural insights from the ALS, researchers optimized the fit between organic and inorganic ions in a perovskite solar-cell material. The work increased the material’s power-conversion efficiency and stability and opens up a new avenue for improving the current-carrier dynamics of a promising class of materials. Read more »PPT-icon-35 PDF-icon-35

ALS in the News (April 2021)

Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology

LONP1 is an AAA+ protease that  maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Herein, we report the development of selective boronic acid-based LONP1 inhibitors using structure-based drug design as well as the first structures of human LONP1 bound to various inhibitors. Read more »

To Design Truly Compostable Plastic, Scientists Take Cues From Nature

Researchers have designed an enzyme-activated compostable plastic that could diminish microplastics pollution and holds great promise for plastics upcycling. The material can be broken down to its building blocks—small individual molecules called monomers—and then reformed into a new compostable plastic product. Read more »

Meteorites Reveal Magnetic Record of Protoplanet Churn

Researchers detected the signatures of ancient magnetic fields imprinted in the ferromagnetic grains of meteorites that originated from the same parent body. The results, combined with radioisotopic dating of the samples, support an extended time frame for the cooling of molten protoplanetary cores. Read more »