Researchers used the SIBYLS beamline to gain insight into ADAMTS13, the only known protein to regulate the adhesive function of von Willebrand factor (VWF), a blood-clotting protein. When VWF is deficient or abnormal, it causes a common inherited bleeding disorder, von Willebrand disease. VWF is also implicated in arterial and deep-vein thrombosis, stroke, atherosclerosis, sickle cell crisis, and sepsis. Read more »
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
PDE4D enzymes are important for normal brain function. Mutations have been asssociated with an ultrarare neurodevelopmental disorder, and genetic variation in PDE4D contributes to biological variation in human cognitive ability. Here, researchers report on novel PDE4D inhibitors providing potent memory-enhancing effects in a mouse model, with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors. Read more »
Superconductor Exhibits “Glassy” Electronic Phase
Researchers discovered that electrons in a high-temperature superconductor can exhibit a new type of collective behavior that is more “glassy” (disordered) than expected. The study provides valuable insight into the nature of collective electron behaviors and how they relate to high-temperature superconductivity. Read more »
Infrared Light Reveals Microstripes at Insulator-Metal Transition
In this study of a current-driven insulator-to-metal transition, a distinctive stripe pattern develops between the insulating and metallic phases. The work reveals remarkable new features of electrically induced insulator-to-metal transitions in materials with potential applications in energy-efficient memory and transistor devices. Read more »
Structural Characterization of a Synthetic Tandem-Domain Bacterial Microcompartment Shell Protein Capable of Forming Icosahedral Shell Assemblies
Bacterial microcompartments (BMCs) are subcellular compartments found in many prokaryotes, and they are of considerable interest for biotechnological applications. The BMC-H2 shell system constitutes a relatively simple generic building block that could be used to construct designed shells with a relatively highly tunable pore. Read more »
Electric Skyrmions Charge Ahead for Next-Generation Data Storage
Researchers have observed chirality for the first time in polar skyrmions in a material with reversible electrical properties. The combination of polar skyrmions and these electrical properties could one day lead to applications such as more powerful data storage devices that hold information even after a device has been powered off. Read more »
Antibody Uses Mimicry to Block SARS Coronavirus
Protein structures not only revealed how SARS and MERS antibodies inhibit the viruses from attaching to host cells, they also revealed an unprecedented example of receptor mimicry that triggers the cell-invasion machinery of the SARS virus. The results inform efforts to prevent and treat these serious, often deadly, respiratory diseases. Read more »
A New Twist in Soft X-Ray Beams
Visible-light beams with orbital angular momentum (OAM) have been used in applications ranging from communications and imaging to particle manipulation. Now, researchers have generated high-quality OAM beams in the soft x-ray regime, with intriguing possibilities for future use at high-coherence, diffraction-limited light sources. Read more »
Mechanical Competence and Bone Quality Develop During Skeletal Growth
Researchers explored how bone quality and mechanical competence progress during longitudinal bone growth. Deformation at the tissue, fibril, and mineral length scales was investigated with mechanical tensile tests during small and wide-angle x-ray scattering/diffraction (SAXS/WAXD) experiments, revealing dramatic differences in mechanical resistance with age. Read more »
The Best Topological Conductor Yet: Spiraling Crystal Is the Key to Exotic Discovery
Researchers have discovered the strongest topological conductor yet, in the form of thin crystal samples that have a spiral-staircase structure. The realization of so-called topological materials—which exhibit exotic, defect-resistant properties and are expected to have applications in electronics, optics, quantum computing, and other fields—has opened up a new realm in materials discovery. Read more »
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