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Guiding Target Selection for COVID-19 Antibody Therapeutics

Protein-structure studies helped demonstrate that the primary target of antibody-based COVID-19 immunity is the part of the virus’s spike protein that can most easily mutate. The work anticipated the rise of SARS-CoV-2 variants and guides the selection of antibody therapeutics that are likely to be more resistant to immune escape. Read more »PPT-icon-35 PDF-icon-35

Programmable Micromagnets for Single-Cell Sorting

Researchers demonstrated that electrically induced mechanical strain can control the magnetic state of tiny magnets used to sort biological cells. The work lays the foundation for a programmable, single-cell sorting platform to support a wide variety of biotechnology applications, including personalized cancer treatments. Read more »PPT-icon-35 PDF-icon-35

How X-Rays Could Make Reliable, Rapid COVID-19 Tests a Reality

A highly sensitive lateral flow assay—the same type of device used in home pregnancy tests—could be developed using pairs of rigid antibodies that bind to the SARS-CoV-2 nucleocapsid protein. SAXS data showed that a particular pair of monoclonal antibodies bound to the nucleocapsid protein very strongly and stably, in part due to the antibodies’ rigidity. Read more »

New Tools Link Catalytic Activity to Nanoscale Transformations

Transitioning to a clean hydrogen economy will require cheaper, more efficient ways to split water molecules. To address bottlenecks in the water-splitting process, researchers developed a suite of advanced tools, including a liquid flow cell that enables electrochemical studies of catalysts under working conditions. Read more »

High-Efficiency Organic Photovoltaics using Eutectic Acceptor Fibrils to Achieve Current Amplification

Researchers report the fabrication of ternary organic solar cells, achieving a significant JSC boost, by virtue of their optimized crystalline feature, with the formation of eutectic crystalline fibrils. The optimal morphology suppresses energetic disorder and nongeminate recombination, and increases charge transfer and transport, yielding a high efficiency of 17.84% with significant current amplification. Read more »

New Poster Will Take You “Inside the ALS”

Peek under the dome for an overview of all the components that enable the ALS to produce extremely bright light ranging from infrared to x-rays. This poster includes images and explanations of ALS equipment from the heart of the accelerator to experimental endstations and how they all fit under our iconic dome. Read more »

In Memoriam: David Shirley, Former Laboratory Director

David Arthur Shirley, former director of Berkeley Lab and professor at the University of California, Berkeley, died on March 29, 2021, of age-related illness. Shirley was a pioneer of electron spectroscopy who spearheaded the creation of the ALS and helped motivate the construction of third-generation synchrotron radiation facilities in the U.S. and around the world. Read more »

Call for 2020 and 2021 Publications

All publications resulting from work done in whole, or in part, at the ALS must be recorded by the User Office for the Department of Energy (DOE). Please help ensure our records are complete by reporting your ALS publications, especially those published in 2020 and 2021. Read more »