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Science Briefs

Designed Protein Nanocages Inspired by Nature

Inspired by protein molecules observed in nature, researchers have now engineered ten large, 120-subunit, two-component protein complexes. These designed nanomaterials are attractive starting points for new approaches to targeted drug delivery, vaccine design, and bioenergy. Read more »

Formation of Toxic Furans during Combustion

Researchers predicted and observed for the first time the formation and growth of furans and other oxygenated hydrocarbons produced during combustion. These compounds can have a wide range of detrimental effects on human health, air quality, and regional and global climate. Read more »

Improving Alloy Memory by Tuning Material Composition

Shape memory alloys can “remember” their original form and return to it repeatedly when heated. To gain structural insight into a new alloy capable of sustaining millions of cycles without failure, researchers performed x-ray Laue microdiffraction at ALS Beamline 12.3.2. Read more »

Validation of Novel Proteins Inspired by Nature

Designed proteins containing hydrogen-bonding modules have been validated by crystallography and SAXS. The ability to design synthetic molecules that combine the specificity of DNA-like binding with protein function opens up huge opportunities for the fields of synthetic biology and materials science. Read more »

A Cleansing Rain Falls; a Soil-Filled Mist Arises

Rain’s reputation for cleansing the air may come with a caveat after new findings, including STXM and NEXAFS data, show that raindrops play a role in generating airborne organic particles. The findings could influence how scientists model our planet’s climate and future. Read more »

Getting to the Root of Grapevine Hydraulics

In grapevines, “root pressure” was assumed to play a role in recovering from embolisms (blockages) in a plant’s water-transport systems during drought conditions. To clarify this, researchers used ALS Beamline 8.3.2 to obtain 3D microtomographic images of grapevine stem segments detached from roots and leaves. Read more »

Mapping the Topology of the Human Genome

To determine how a gene will function, we need to know the spatial arrangement of the genome in the nucleus. Researchers have made a significant advance in determining this 3D organization by combining modeling and probabilistic calculations with minimally perturbing imaging techniques. Read more »

A Novel Quasi-1D Topological Insulator

The tantalizing prospect of energy-saving, ultralow-power electronics has led to a vigorous search for optimal topological insulator materials. Now, an international team of scientists has discovered the first of a new class of topological insulators with unique properties: quasi-1D bismuth iodide. Read more »

Understanding the Key to Henipavirus Infection

The Hendra virus was the first member of the genus Henipavirus, an emergent group of viruses with a high mortality rate. Knowledge of the protein structure that mediates Hendra entry into host cells could enable the design of antigens with improved immunogenic response. Read more »

Power-Amplified Predatory Strikes in Trap-Jaw Spiders

Using a combination of high-speed video, molecular phylogenetic analysis, and x-ray microtomography of a family of tiny trap-jaw spiders, researchers discovered that power-amplified predatory strikes evolved four times independently, once the basic trap-jaw body plan was in place. Read more »