A team of scientists designed and validated via x-ray crystallographic studies a fluorescent protein (CaMPARI) that allows the permanent marking of active brain cells. The protein was then used to study live changes via fluorescence in the active nerve cells in brains of fruit flies, zebrafish, and mice. Read more »
Science Highlights
Signal Speed in Nanomagnetic Logic Chains
A time-resolved x-ray imaging technique directly observes signal propagation dynamics in nanomagnetic logic (NML) chains. The technique can assess NML reliability on fast time scales and help optimize chain engineering for this promising ultralow-power computing architecture. Read more »
Carotenoid Pigment Is the Key to Photoprotection
A technique newly available at the ALS has enabled the discovery of a surprising key event in photosynthetic systems. A protein shifting from an “orange” light-absorbing state to a “red” photoprotective state turns out to be an unanticipated molecular priming event in photoprotection. Read more »
Ancient Proteins Help Unravel a Modern Cancer Drug’s Mechanism
The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. Researchers at the ALS have uncovered exactly why that is the case, pointing to novel methods of drug discovery. Read more »
Tracking the Elusive QOOH Radical
For the first time, researchers directly observed QOOH molecules, a class of highly reactive molecules at the center of the web of ignition chemistry reactions. The data generated will improve the fidelity of combustion models used to create cleaner and more efficient cars and trucks. Read more »
Spectroscopy of Supercapacitor Electrodes In Operando
X-ray spectroscopy of graphene supercapacitor electrodes under operating conditions reveals changes in electronic structure and bonding. The research could lead to an improvement in the capacity and efficiency of electrical energy storage systems needed to meet the burgeoning demands of consumer, industrial, and green technologies. Read more »
ALS X-Rays Shine a New Light on Catalysis
Recently a team of Stanford and Berkeley Lab researchers used x-rays at the ALS in a novel way to observe the behavior of electrons during technologically important chemical reactions in metal oxide electrocatalysts. What they learned has upended long-held scientific understanding of how these catalysts work. Read more »
A Fullerene that Breaks the Rules
Scientists used small-molecule x-ray crystallography to verify and characterize the first non-functionalized fullerene with a heptagonal ring in the cage. This new molecule changes the definition of a classical fullerene and expands the range of structural possibilities for endohedral fullerenes. Read more »
Peptoid Nanosheets Offer a Diversity of Functionalities
Researchers at the ALS have recently observed peptoid nanosheets as they self-assemble at an oil–water interface. This development opens the door to designing peptoid nanosheets of increasing complexity and functionality for a broad range of applications, including improved chemical sensors and separators, and safer, more effective drug-delivery vehicles. Read more »
Molecular Structure of Water at Gold Electrodes Revealed
ALS researchers have now made a first-ever observation of the molecular structure of liquid water at a gold surface under different charging conditions. This marks the first time that the scientific community has been able to achieve such high sensitivity in an in situ environment under working electrode conditions. Read more »
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