Sickle cell disease (SCD), which affects millions of people worldwide, has traditionally been treated with a cytotoxic drug that has a range of negative side effects and variable patient response. Bay Area biopharmaceutical company Global Blood Therapeutics (GBT) is on a mission to develop a better treatment and is using the ALS to help. ... Read more »
The actions of a protein used for DNA replication and repair are guided by electrostatic forces known as phosphate steering, a finding that not only reveals key details about a vital process in healthy cells, but provides new directions for cancer treatment research. ... Read more »
Scientists found that the element berkelium breaks form with its heavy-element peers by taking on an extra positive charge when bound to a synthetic organic molecule. This property could help scientists develop better methods for handling and purifying nuclear materials. ... Read more »
Proteins consisting of identical subunits arranged symmetrically around a central axis (cyclic homo-oligomers) play key roles in many biological processes. Researchers have now developed a systematic approach to their design and demonstrated its accuracy using protein crystallography and small-angle x-ray scattering. ... Read more »
Researchers at the ALS have recently observed peptoid nanosheets as they self-assemble at an oil–water interface. This development opens the door to designing peptoid nanosheets of increasing complexity and functionality for a broad range of applications, including improved chemical sensors and separators, and safer, more effective drug-delivery vehicles.
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