A major challenge of computational structural biology has been to create, from scratch, new proteins with heretofore unobserved three-dimensional structures. Researchers have now developed and demonstrated a methodology for protein-structure prediction and design by creating the first artificial globular protein with a novel topology. Significantly, the x-ray structure agreed almost precisely with the structure specified by the computational model. Read more »
ALS Work Using Scattering/Diffraction
These techniques make use of the patterns of light produced when x-rays are deflected by the closely spaced lattice of atoms in solids and are commonly used to determine the structures of crystals and large molecules such as proteins.
The Path of Messenger RNA through the Ribosome
Using x-ray crystallography, researchers directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 Å resolution. Image depicts the view down the crystallographic 4-fold axis of the 70S ribosome-mRNA-tRNA complex, showing the head-to-tail juxtaposition of the model mRNAs (red-orange) between adjacent ribosomes. Read more »
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