A promising anticancer drug, AMG 510, was developed by Amgen Inc. with the help of novel structural insights gained from protein structures solved at the ALS. AMG 510, which is currently in phase II clinical trials for efficacy, targets tumors caused by mutations in the KRAS protein, one of the most common causes of cancer. Read more »
Probing the Evolution of Photovoltaic Films during the Spin-Coating Process
A new, in-beamline spin-coating platform enabled researchers to probe the structure of a promising photovoltaic material in the crucial early stages of processing. The results demonstrate the power of multimodal in situ techniques as promising tools for optimizing synthesis parameters and, thus, device performance. Read more »
Berkeley Lab Helps Reveal How Dinosaur Blood Vessels Can Preserve Through the Ages
A team of scientists used infrared and x-ray imaging performed at the Advanced Light Source to determine the chemical mechanisms that allow soft tissue structures to persist in dinosaur bones—countering the long-standing scientific dogma that protein-based body parts can’t survive more than 1 million years. Read more »
X-Ray Technology Sheds New Light on Antibiotic Synthesis
Atomic-scale structural analyses performed at the ALS are helping scientists understand the inner workings of the enzyme “assembly lines” that microbes use to produce an important class of compounds, many of which have uses as antibiotics, antifungals, and immunosuppressants. Read more »
Light Sources Form Data Solution Task Force
With funding from DOE for a two-year pilot program, scientists from the five light sources have formed a Data Solution Task Force that will demonstrate, build, and implement software, cyberinfrastructure, and algorithms that address universal needs between all five facilities. These needs range from real-time data analysis capabilities to data storage and archival resources. Read more »
77Se NMR Probes the Protein Environment of Selenomethionine
Sulfur is critical for protein structure and function but lacks a sensitive isotope for nuclear magnetic resonance (NMR) experiments. This can be circumvented by substituting sulfur with selenium, which has an NMR-compatible isotope (77Se). To enable interpretation of the NMR data, the structures of five of protein variants were solved by x-ray crystallography to a resolution of 1.2 Å. Read more »
Turning Up the Heat on Antibacterial-Resistant Diseases
Scientists have designed a biocompatible polymer that has the potential to advance photothermal therapy, a technique that deploys near-infrared light to combat antibacterial-resistant infections and cancer. The team synthesized the polymer by stringing together small molecules called ionic azaquinodimethanes, which they characterized at the ALS. Read more »
New Catalyst Resists Destructive Carbon Buildup in Electrodes
Key challenges in the transition to sustainable energy can be met by converting CO2 to CO through the use of solid oxide electrolysis cells. But because these can suffer from carbon deposition at the electrodes, researchers have now identified and tested a new, cerium oxide–based catalyst that is more resistant to carbon buildup. Read more »
Molecular Handle Enables Viral Attack on Joint Cells
A collaboration of university and industry researchers used x-ray crystallography to investigate how the chikungunya virus, which can cause debilitating joint pain, engages a receptor protein found on the surfaces of joint cells. The work provides a path forward in the fight against a family of viruses that can result in acute and chronic arthritis. Read more »
Crystallography Reveals How New Molecular Cages Trap Toxic Gases
Current technologies for reducing toxic gas emissions are often ineffective and wasteful. Crystallographic analyses of two new MOF materials revealed how they reversibly bind their target gases, enabling the materials to be reused over many cycles (reducing waste) and permitting subsequent conversion of the gases into valuable chemical products. Read more »
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