Antimony is considered a priority environmental pollutant by the EPA. The ant operon of the antimony-mining bacterium, C. testosterone, confers resistance to Sb(III). The operon is regulated by the product of the first gene in the operon, antR. This is the first report of the structure and binding properties of antR, with high selectivity for environmental antimony. Read more »
Journal Covers
Extreme Ultraviolet Second Harmonic Generation Spectroscopy in a Polar Metal
Berger et al. utilize extreme ultraviolet, second-harmonic generation (XUV-SHG) spectroscopy to investigate the polar metal phase of lithium osmate (LiOsO3), where the coexistence of polarity and metallicity is unexpected. As the first demonstration of XUV-SHG spectroscopy around a phase transition, these results pave the way for using nonlinear XUV methods to investigate broken symmetry from an element-specific perspective. Read more »
Rapid In Situ Ligand-Exchange Process Used to Prepare 3D PbSe Nanocrystal Superlattice Infrared Photodetectors
A new strategy for retaining long-range order during ligand exchange of nanocrystal superlattices is used to construct PbSe infrared photodetectors. The ordered photodetectors have a 16× higher responsivity and 2× faster response time compared to disordered ones. Read more »
Conformational Dynamics in the Interaction of SARS-CoV-2 Papain-like Protease with Human Interferon-Stimulated Gene 15 Protein
The image depicts the complex formed between SARS-CoV-2 papain-like protease and human interferon-stimulated gene 15 protein. Small-angle scattering elucidated the structural details of this complex providing insight into its role in suppressing the innate immune response and also potential routes for development of therapeutics to combat COVID-19. Read more »
Understanding the Hydrothermal Formation of NaNbO3: Its Full Reaction Scheme and Kinetics
To understand and tune the properties of hydrothermally produced NaNbO3, the reaction was studied in situ with powder x-ray diffraction, small-angle scattering, and total scattering with pair-distribution function analysis. The full reaction scheme and kinetics were revealed, showing two different temperature-dependent growth mechanisms. Read more »
Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor
van der Waals sphere representation of the factor VIII C1 domain, highlighting surface‐exposed hemophilia A–associated mutations that cause impaired von Willebrand factor binding and overlap with a pathogenic anti‐C1 domain inhibitor epitope. Read more »
Single-Domain Multiferroic Array-Addressable Terfenol-D (SMArT) Micromagnets for Programmable Single-Cell Capture and Release
Researchers develop programmable multiferroic micromotors that enable single-cell manipulation based on time-dependent functions of individual cells, such as cell secretion. Smart programmable multiferroic materials lay the groundwork for large-scale automated single-cell sorting and enable a broad spectrum of biotechnology applications. Read more »
High-Efficiency Organic Photovoltaics using Eutectic Acceptor Fibrils to Achieve Current Amplification
Researchers report the fabrication of ternary organic solar cells, achieving a significant JSC boost, by virtue of their optimized crystalline feature, with the formation of eutectic crystalline fibrils. The optimal morphology suppresses energetic disorder and nongeminate recombination, and increases charge transfer and transport, yielding a high efficiency of 17.84% with significant current amplification. Read more »
Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Herein, we report the development of selective boronic acid-based LONP1 inhibitors using structure-based drug design as well as the first structures of human LONP1 bound to various inhibitors. Read more »
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
The cover feature shows a chessboard (representative of KRAS mutant cells) and how the concerted action of the MEK inhibitor cobimetinib (rook) and the new selective pan-RAF inhibitor GNE-0749 (queen) force the opposing king (phospho-ERK, the downstream signaling node of RAF and MEK) into checkmate. Read more »
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