Mutations in rhodopsin can cause misfolding and aggregation of the receptor, which leads to retinitis pigmentosa, a progressive retinal degenerative disease. Förster resonance energy transfer (FRET) and Fourier transform infrared (FTIR) microspectroscopy were utilized to probe within cells the structures formed by G188R and P23H opsins. Read more »
All News & Updates
Signal Speed in Nanomagnetic Logic Chains
A time-resolved x-ray imaging technique directly observes signal propagation dynamics in nanomagnetic logic (NML) chains. The technique can assess NML reliability on fast time scales and help optimize chain engineering for this promising ultralow-power computing architecture. Read more »
Wolfgang Eberhardt on Light Sources: Getting the Balance Right
Wolfgang Eberhardt, an internationally respected expert on synchrotrons, is wrapping up an extended visit to the ALS. Between experiments furthering our understanding of organic solar-cell materials, he discusses the relative merits of diffraction-limited storage rings (such as the proposed ALS upgrade, ALS-U) and free-electron laser facilites. Read more »
User Experiment Safety Process Update: For Experiments After August 17
The ALS has updated its User Experiment Safety Process. The main change that will affect users is a new requirement to complete an Experiment Safety Sheet (ESS) for each visit and for each beamline. This is a change from current procedure where an ESS can be valid for up to one year and may cover more than one beamline. Read more »
Footprinting Technique Gives ALS Users New Insights
The x-ray footprinting (XFP) technique developed at ALS Beamline 5.3.1 gives researchers a powerful tool for the study of macromolecular structures and dynamics of proteins and nucleic acids in solution. Read more »
Ken Chow, ALS Engineering Lead
In his new role as ALS Engineering Lead, Ken Chow has taken on a consolidated role that was previously split between mechanical and electrical. As of August, a reorganization of ALS engineering has Chow overseeing all engineering tasks at the ALS, which includes magnetic and vacuum systems, mechanical engineering and technology, and electrical and controls engineering. Read more »
Carotenoid Pigment Is the Key to Photoprotection
A technique newly available at the ALS has enabled the discovery of a surprising key event in photosynthetic systems. A protein shifting from an “orange” light-absorbing state to a “red” photoprotective state turns out to be an unanticipated molecular priming event in photoprotection. Read more »
Narrowly Distributed Crystal Orientation in Biomineral Vaterite
The cover shows a scanning electron micrograph of vaterite crystals formed by the sea squirt Herdmania momus. These are the largest single crystals of vaterite ever observed, including biogenic, geologic or synthetic vaterite. Flat crystal faces are uncommon in biogenic crystals, but these crystals are clearly hexagonal pyramids. Pokroy et al. show that these crystals have smooth fracture surfaces; thus, they most likely formed ion-by-ion, rather than by attachment of particles. Narrowly distributed orientations and lack of organics at crystal interfaces suggest a new mechanism of biomineral crystal growth, perhaps spherulitic growth from solution. Read more »
Ancient Proteins Help Unravel a Modern Cancer Drug’s Mechanism
The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. Researchers at the ALS have uncovered exactly why that is the case, pointing to novel methods of drug discovery. Read more »
Tracking the Elusive QOOH Radical
For the first time, researchers directly observed QOOH molecules, a class of highly reactive molecules at the center of the web of ignition chemistry reactions. The data generated will improve the fidelity of combustion models used to create cleaner and more efficient cars and trucks. Read more »
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