Scientists have mapped the reorganization of genetic material that takes place when a stem cell matures into a nerve cell. Detailed 3-D visualizations show an unexpected connectivity in the genetic material in a cell’s nucleus, and provide a new understanding of a cell’s evolving architecture. Read more »
What I Did Last Summer: Co-Authored a Scientific Paper!
Young ALS user Jessica Guo may still be in high school, but she already has a peer-reviewed journal publication to her credit, based on work done at the ALS. She is a co-author of a paper published in Biology of the Cell on mesoscale imaging with cryo-light and x-rays. Read more »
Molecular Switch Triggers Bacterial Pathogenicity
Using an array of high-powered x-ray imaging techniques at the ALS, scientists have revealed for the first time the molecular steps that turn on bacteria’s pathogenic genes. The study could open up new avenues in the development of drugs to prevent or treat bacterial infection. Read more »
Mapping the Topology of the Human Genome
To determine how a gene will function, we need to know the spatial arrangement of the genome in the nucleus. Researchers have made a significant advance in determining this 3D organization by combining modeling and probabilistic calculations with minimally perturbing imaging techniques. Read more »