Researchers solved the structure of a bacterial toxin bound to a neutralizing protein, revealing two distinct mechanisms for how the toxin-producing bacteria avoid poisoning themselves. The findings offer clues to the evolutionary origins of the potent toxins that enable bacterial pathogens to cause human diseases such as cholera and diphtheria. Read more »
Science Highlights
Toward a Blueprint for Anti-influenza Drugs
Researchers obtained high-resolution structures of several influenza antiviral drug molecules bound to their proton-channel targets in both open and closed conformations. The structures provide an atomic-level blueprint from which to design more effective anti-influenza drugs that can overcome growing drug resistance. Read more »
The Smoking Gun of Soot Formation
Scientists identified a mechanism for the formation of soot involving a series rapid chemical reactions rather than the typical condensation of particles from gas. The results are critical to developing methods for controlling emissions responsible for millions of deaths annually, severe degradation of air quality, and enhanced global warming. Read more »
Expanding the Infrared Nanospectroscopy Window
An innovative infrared-light probe with nanoscale spatial resolution has been expanded to cover previously inaccessible far-infrared wavelengths. The ability to investigate heterogeneous materials at nanometer scales and far-infrared energies will benefit a wide range of fields, from condensed matter physics to biology. Read more »
Targeting Bacteria That Cause Meningitis and Sepsis
Researchers determined the structure of a human antibody that broadly protects against a bacterium that causes meningitis and sepsis. The work provides molecular-level information about how the antibody confers broad immunity against a variable target and suggests strategies for further improvement of available vaccines. Read more »
Clues to the Solar System’s Original “Bricks and Mortar”
In comet dust, researchers discovered composite organic-inorganic mineral grains that are likely to be the original “bricks and mortar” of the solar system. “Forensic” samples preserved from the birth of the solar system allow investigations into the nature of the atomic and molecular ancestry of the terrestrial planets and life on Earth. Read more »
A 2D Lattice of Molecular Qubits for Quantum Computing
Researchers developed a way to build a 2D lattice of molecular-spin qubits (quantum bits of information), with control over qubit orientation and localization. The work enables the integration of molecular quantum-information hardware into the scalable, robust, solid-state architectures needed for performing quantum computation. Read more »
Structure Reveals Mechanism Behind Periodic Paralysis
X-ray crystallography of a membrane protein provided a structural understanding of how a single mutation can result in periodic muscle paralysis. The results suggest possible drug designs that could provide relief to patients with a genetic disorder that causes them to be overcome suddenly with profound muscle weakness. Read more »
Graphene-Based Catalyst Improves Peroxide Production
Scientists characterized a graphene-based electrocatalyst that potentially makes the production of hydrogen peroxide more selective, efficient, and cost effective. Hydrogen peroxide is an important commodity chemical with growing demand in many areas, including the electronics industry, wastewater treatment, and paper recycling. Read more »
A Designed Material Untangles Long-Standing Puzzle
The origin of the metal-to-insulator transition in a key material system was revealed by nanostructures designed to decouple simultaneous phase transitions. This approach could lead to new materials with emergent physics and unique electronic properties, supporting broader research efforts to revolutionize modern electronics. Read more »
- « Previous Page
- 1
- …
- 12
- 13
- 14
- 15
- 16
- …
- 25
- Next Page »