An antibody was modified to activate a specific pathway of the immune system, demonstrating its value in killing tumor cells. The work provides a platform for disentangling different immune-system pathways and could lead to the design of improved immunotherapies. Read more »
Genentech Advances Research Toward Better Medicines to Lower Cholesterol
Genentech has been working in collaboration with the ALS for years with the goal of identifying a better cholesterol treatment mechanism that targets a cholesterol-regulating protein in the body known as PCSK9. Recent advances in understanding PCSK9’s structure have put them closer to that goal. Read more »
X-Rays Reveal the Biting Truth About Parrotfish Teeth
A parrotfish’s hardy teeth allow it to chomp on coral all day long, ultimately grinding it up through digestion into fine sand. Researchers wanting to see how the fine crystal structure of parrotfish teeth contribute to their incredible strength were able to visualize the orientation of individual crystals, which showed their intricately woven structure. Read more »
X-Ray Footprinting Solves Mystery of Metal-Breathing Protein
Scientists have discovered the details of an unconventional coupling between a bacterial protein and a mineral that allows the bacterium to breathe when oxygen is not available. The research could lead to innovations in linking proteins to other materials for bioelectronic devices such as sensors that can diagnose disease or detect contaminants. Read more »
NIH Grant Will Enhance Structural Biology Research Experience for ALS Users
A recently awarded National Institutes of Health (NIH) grant will help integrate existing structural biology resources at the ALS to better serve users. The funds will help establish a centralized collaborative mechanism, called ALS-ENABLE, that will guide users through the most appropriate routes for answering their biological questions. Read more »
Exploring the Roots of Photosynthesis in a Soil-Dwelling Bacterium
The bacterium, H. modesticaldum, is thought to have a photosynthetic reaction center resembling the earliest common ancestor of all photosynthesis complexes. Its molecular structure has now been solved, providing insight into the evolution of photosynthesis and how nature optimized light-driven energy collection. Read more »
The CRISPR Target-Recognition Mechanism
CRISPR-associated (Cas) proteins have revolutionized gene editing by vastly simplifying the insertion of short snippets of new (“donor”) DNA into very specific locations of target DNA. Now, researchers have discovered how the Cas proteins are able to recognize the target locations with such great specificity. Read more »
Microbes Linked to Drier Human Skin
Genetic analyses and infrared studies have found that archaea, a type of microbe commonly found in extreme environments, are also found on human skin. The results suggest that an increase in archaea is linked to reduced skin moisture and that they are most abundant in subjects younger than 12 and older than 60. Read more »
ALS Work Highlighted in DOE Top 40 Countdown
To celebrate DOE’s 40th anniversary (October 1, 2017), the Office of Science (SC) collected 40 scientific milestones from the previous 40 years, each one supported by SC. The ALS played a key role in two of the milestones: 2005 (ribosome) and 2009 (topological materials). Read more »
Global Blood Therapeutics Uses ALS to Tackle Sickle Cell Disease
Sickle cell disease (SCD), which affects millions of people worldwide, has traditionally been treated with a cytotoxic drug that has a range of negative side effects and variable patient response. Bay Area biopharmaceutical company Global Blood Therapeutics (GBT) is on a mission to develop a better treatment and is using the ALS to help. Read more »
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