Genentech has developed a unique one-armed antibody, onartuzumab, which is now in late-stage clinical trials in multiple cancer types. The company used crystal structures obtained at ALS Beamline 5.0.2 to demonstrate the mechanism of action of this unique potentially therapeutic antibody. Read more »
ALS research has shown how the scales of a freshwater fish found in the Amazon Basin can literally re-orient themselves in real time to resist force, in essence creating an adaptable body armor. Read more »
Berkeley Lab and University of California researchers have developed a new technique for monitoring protein phosphorylation inside single living cells, enabling them to follow live cellular chemical changes without bias and without harming the cells. Read more »
Almost all bacteria can form biofilms—dynamic communities of cells enclosed in self-produced matrices of polymers. Researchers have developed a robust and label-free method to probe the chemical underpinnings of developing bacterial biofilms. Read more »
Scientists have gotten their first detailed look at the molecular structure of an enzyme that Nature has been using for eons to help silence unwanted genetic messages: Dicer, an enzyme that plays a critical role in a process known as RNA interference.
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RNA, like protein, can sometimes function as an enzyme (ribozyme) to speed biochemical reaction rates. But how does RNA, a simple polymer, enhance reaction rates by at least a million fold? Researchers obtained the structures of a ribozyme trapped in different states of its catalytic cycle, showing how a change in the RNA conformation governs the reaction mechanism. Read more »