In this work, researchers illustrated the potential of soft x-ray tomography to rapidly characterize and quantify the structural changes induced in cells infected by SARS-CoV-2, revealing profound alterations of the subcellular architecture induced by viral infection over time. Read more »
New Device Advances Commercial Viability of Solar Fuels
A Berkeley Lab research team developed a new artificial photosynthesis device component that exhibits remarkable stability and longevity as it selectively converts sunlight and carbon dioxide into two promising sources of renewable fuels—ethylene and hydrogen. Read more »
An Antibody That Broadly Neutralizes SARS-CoV-2
An antibody that appears to neutralize all known SARS-CoV-2 strains and closely related coronaviruses was discovered with the help of the ALS. The work highlights principles underlying antibody potency, breadth, and escapability that can guide the development of therapeutics against the current and potential future pandemics. Read more »
Sounding the Antiviral Alarm: A New Family of Immune-System Sensors
Comparison of enzyme structures from humans and insects revealed a new family of evolutionarily related immune-system sensors, triggered by viral RNA or DNA to produce tailored signals that initiate antiviral action. The results shed new light on the diversity and development of immune defenses in animals. Read more »
Cell ‘Fingerprinting’ Could Yield Long-Awaited Alzheimer’s Disease Diagnostic
A new application of infrared spectromicroscopy analyzes cells for signs of Alzheimer’s disease by measuring how the molecules in cells vibrate upon exposure to infrared light. The vibrational profile of each sample is so distinct and the difference between diseased and healthy cell samples is so visible that researchers liken the process to “cellular fingerprinting.” Read more »
Autonomous Data Acquisition for Scientific Discovery
Researchers at large scientific facilities such as the ALS have applied a robust machine-learning technique to automatically optimize data gathering for a variety of experimental techniques. The work promises to enable experiments with large, complex datasets to be run more quickly, efficiently, and with minimal human intervention. Read more »
Functional and structural characterization of AntR, an Sb(III) responsive transcriptional repressor
Antimony is considered a priority environmental pollutant by the EPA. The ant operon of the antimony-mining bacterium, C. testosterone, confers resistance to Sb(III). The operon is regulated by the product of the first gene in the operon, antR. This is the first report of the structure and binding properties of antR, with high selectivity for environmental antimony. Read more »
Assembly of the SARS-CoV-2 Replication Mechanism
Using a multimodal approach that included x-ray scattering at the ALS, researchers determined how components of the SARS-CoV-2 replication mechanism fit together. A better understanding of how this protein complex works provides insight into potential structural or functional weak spots to exploit for drug development. Read more »
Deconstructing the Infectious Machinery of the SARS-CoV-2 Virus
Scientists collaborated to model the complex protein responsible for SARS-CoV-2 replication, revealing its potential weak spots for drug development. The investigation hinged on data collected from many advanced imaging techniques, including small-angle x-ray scattering (SAXS), crystallography, and small-angle neutron scattering (SANS). Read more »
Conformational Dynamics in the Interaction of SARS-CoV-2 Papain-like Protease with Human Interferon-Stimulated Gene 15 Protein
The image depicts the complex formed between SARS-CoV-2 papain-like protease and human interferon-stimulated gene 15 protein. Small-angle scattering elucidated the structural details of this complex providing insight into its role in suppressing the innate immune response and also potential routes for development of therapeutics to combat COVID-19. Read more »
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