Researchers found that a symbiont capable of fixing nitrogen (turning it into a biologically usable form) has evolved into an organelle—an intrinsic part of the algae cells that host it. The discovery is of great interest for understanding organelle genesis and for efforts to engineer agricultural plants with built-in nitrogen-fixing capabilities. Read more »
Scientists Discover First Nitrogen-Fixing Organelle
In two recent papers, an international team of scientists describe the first known nitrogen-fixing organelle within a eukaryotic cell. The organelle is the fourth example in history of primary endosymbiosis—the process by which a prokaryotic cell is engulfed by a eukaryotic cell and evolves beyond symbiosis into an organelle. Read more »
Clarifying the FLASH Effect for Cancer Radiation Therapy
To clarify the underlying mechanisms of the FLASH effect, in which the delivery of ultrafast, high-intensity doses of radiation to tumors counterintuitively reduces damage to surrounding healthy cells, researchers directly compared the oxidative effects of conventional and FLASH techniques using x-ray footprinting at the ALS. Read more »
Bifurcation of High- and Low-Energy Electrons in Microbial Metabolism
A class of chemical reaction found only in biology, electron bifurcation channels two electrons from one donor to two separate acceptors, with one electron elevated in energy at the expense of lowering the energy of the second. Researchers used the ALS to study this process in a microbial protein involved in this bioenergetic pathway. Read more »
Tracking the Breakdown of Cellulose at the Micron Scale
A time-resolved study using infrared spectromicroscopy in a carefully controlled environment revealed why enzymes get bogged down when trying to break up cellulose from plants. The work sheds new light on the challenge of extracting the sugars locked up in plants for use in making petroleum-free fuels, chemicals, and medicines. Read more »
Watching the Enzymes that Convert Plant Fiber into Simple Sugars
Research from Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory, and UC Davis sheds new light on how to access the sugars locked up in plants to produce petroleum-free fuels, chemicals, and medicines. The technique used combines a novel microfluidic device and infrared spectroscopy to study how a cellulose-degrading enzyme works in real time. Read more »
Computer-Aided Protein Design for New Biomaterials
Using a computer-based approach, researchers designed porous protein crystals that were revealed to be stable, tunable, and atomically accurate using x-ray scattering and diffraction at the ALS. The work provides a powerful new platform for biological materials engineering and opens up wide applications in biotechnology and medicine. Read more »
How Structure Affects the Activity of Lipid Nanoparticles
Berkeley Lab and Genentech scientists related the internal structures of lipid nanoparticles to their efficacy at drug delivery, using a combination of methods including x-ray scattering at the ALS. The work promises to expedite the development of drug delivery systems for the treatment of diseases such as COVID-19 and cancer. Read more »
A New Pathway for Clearing Misfolded Proteins
Researchers integrated several approaches, such as cryogenic 3D imaging at the ALS, to define a novel cellular pathway—involving a shared “garbage dump”—for clearing misfolded proteins from cells. The pathway is a potential therapy target for age-related diseases like Alzheimer’s, Huntington’s, and Parkinson’s diseases. Read more »
Breaking Barriers in Drug Delivery with Better Lipid Nanoparticles
A collaboration between Berkeley Lab and Genentech, a member of the Roche Group, is working to break through some of the drug delivery bottlenecks by designing the most effective lipid nanoparticles (LNPs)—tiny spherical pouches made of fatty molecules that encapsulate therapeutic agents until they dock with cell membranes and release their contents. Read more »
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