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ALS Work Using Scattering/Diffraction

These techniques make use of the patterns of light produced when x-rays are deflected by the closely spaced lattice of atoms in solids and are commonly used to determine the structures of crystals and large molecules such as proteins.

 

Probing Composite Materials to Make Better Batteries

Researchers found that when an ion-conducting polymer composite is placed in an electric field, it forms ion-rich hotspots that continue to grow for hours after the field is removed. The study opens a new path to understanding the dynamic structure of composite materials for smaller, lighter batteries. Read more »PPT-icon-35 PDF-icon-35

Construction, characterization and crystal structure of a fluorescent single-chain Fv chimera

In vitro display technologies based on phage and yeast have a successful history of selecting single-chain variable fragment (scFv) antibodies against various targets. However, single-chain antibodies are often unstable and poorly expressed. We explore the feasibility of converting scFv antibodies to an intrinsically fluorescent format by inserting a monomeric, stable fluorescent protein between the light- and heavy-chain variable regions. Read more »

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

A number of clinically validated drugs have been developed by repurposing the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex with molecular glue degraders to eliminate disease-driving proteins. Here, we present the identification of a first-in-class GSPT1-selective cereblon E3 ligase modulator, CC-90009, that targets acute myeloid leukemia blasts and leukemia stem cells. Read more »

Stacking the Deck for Custom-Built Hybrid Materials

Researchers fabricated an electronically coupled heterostructure from a novel semiconducting 2D polymer and a 2D transition metal dichalcogenide. Dramatic optical and electronic changes emerged as polymer thickness decreased, underscoring the potential for the discovery of emergent phenomena in studies of hybrid heterostructures. Read more »

Inhalable COVID-19 Protection via Synthetic Nanobodies

Protein structures obtained in part at the ALS helped researchers to increase the potency of simplified antibodies (nanobodies) designed to neutralize SARS-CoV-2. Stable enough to be used in inhalers or nasal sprays, the nanobodies offer a new option, aside from injected vaccines, for COVID-19 prevention and treatment. Read more »PPT-icon-35 PDF-icon-35

Molecular Complex Removes Copper Ions from Water

X-ray analyses provided key insights into the copper uptake mechanisms in a new organic-inorganic hybrid material that quickly and selectively removes copper ions from water. The material provides an efficient tool for copper remediation as well as a blueprint for creating other hybrid materials for removing toxic metals from water. Read more »PPT-icon-35 PDF-icon-35

Newly Discovered Photosynthesis Enzyme Yields Evolutionary Clues

Scientists have discovered a primitive form of rubisco, a photosynthesis enzyme that has helped shape life on Earth. Detailed information about its structure, determined using complementary techniques at the ALS, will help scientists understand how carbon-fixing organisms oxygenated the atmosphere and how modern plants evolved. Read more »