Researchers integrated several approaches, such as cryogenic 3D imaging at the ALS, to define a novel cellular pathway—involving a shared “garbage dump”—for clearing misfolded proteins from cells. The pathway is a potential therapy target for age-related diseases like Alzheimer’s, Huntington’s, and Parkinson’s diseases. Read more »
ALS Work Using Tomography
Tomography allows 3D imaging of structures inside samples without the need to physically slice them open. A series of images is collected as a sample is rotated, and the raw data is computationally converted into digital sections that can be stacked to reconstruct 3D visualizations of the sample. The very high flux of x-rays and infrared light at the ALS allows collection of high-quality, high-speed 3D images at nanometer or micrometer resolution. Synchrotron tomography also enables photon-energy tuning for element- and chemistry-specific contrast, as well as phase-contrast imaging.
In Fruit-Fly Gut, Bacterial Niche Gets Remodeled for New Arrivals
Researchers found that fruit flies have a specialized niche in their digestive tracts that selects, maintains, and controls bacteria that benefit the fly. Colonization by one type of bacteria physically remodels the niche, promoting secondary colonization by unrelated bacteria. The results will help dissect the mechanisms of host-microbe symbiosis. Read more »
Structural organization of the spongy mesophyll
Many leaves have two layers of photosynthetic tissue: the palisade and spongy mesophyll. The latter is not well characterized and often treated as a random assemblage of irregularly shaped cells. These results show that simple principles may govern the organization and scaling of the spongy mesophyll in many plants and demonstrate the presence of structural patterns associated with leaf function. Read more »
Safely Studying Dangerous Infections Just Got a Lot Easier
Researchers have cranked up the speed of imaging infected cells using soft x-ray tomography, a technique that can generate incredibly detailed, three-dimensional scans. The approach gives an easy way to quickly examine how cells’ internal machinery responds to SARS-CoV-2, or other pathogens, as well as how the cells respond to drugs designed to treat the infection. Read more »
Rapid 3D Visualization of Lung Cells Altered by SARS-CoV-2
In this work, researchers illustrated the potential of soft x-ray tomography to rapidly characterize and quantify the structural changes induced in cells infected by SARS-CoV-2, revealing profound alterations of the subcellular architecture induced by viral infection over time. Read more »
The three-dimensional construction of leaves is coordinated with water use efficiency in conifers
3D anatomical views of conifer leaves with diverse morphologies, generated using synchrotron microCT imaging (colors show different segmented tissues). Top–bottom: Pinus monticola, P. pungens, and Wollemia nobilis. Image courtesy of Santiago Trueba. Read more »
New Technique Visualizes Every Pigment Cell of Zebrafish in 3D
Researchers developed a new technique that uses x-ray microtomography and silver staining to image every pigment cell of a whole zebrafish in 3D. The method could be used to learn more about the 3D architecture of melanoma tumors and potentially guide treatment decisions. Read more »
Strategies for Reducing Platinum Waste in Fuel Cells
Industry and university researchers used the ALS to explore why the platinum used as a catalyst in hydrogen fuel cells degrades unevenly. The resulting knowledge has enabled the development of simple, effective strategies to reduce the waste of precious catalyst material, lowering the costs associated with a promising green technology. Read more »
3D View Reveals Shadow Effect after Rapid Battery Charging
Using 3D x-ray microtomography, researchers measured the lithiation levels of particles in Li-ion battery electrodes during charging. At faster charging rates, lithium metal accumulated on the electrode surface and created a “shadow effect,” a region of poor lithiation in the electrode at some distance away from the lithium plating. Read more »
In a Hawaiian Lava Fountain, Fluid Magma Turns Brittle
Compared to the violent explosions of Mount Vesuvius or Mount St. Helens, Hawaiian volcanic eruptions are relatively calm, characterized by flowing rivers and fountains of lava. Here, researchers have discovered that even low-viscosity magma sometimes behaves more like brittle glass that shatters into fine particles. Read more »
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