Modular self-assembly of biomolecules in two dimensions (2D) is straightforward with DNA but has been difficult to realize with proteins, due to the lack of modular specificity similar to Watson–Crick base pairing. Here, researchers describe a general approach to designing 2D arrays using de novo designed pseudosymmetric protein building blocks. Read more »
All News & Updates
Exploring the “minimal” structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering
Researchers used the SIBYLS beamline to gain insight into ADAMTS13, the only known protein to regulate the adhesive function of von Willebrand factor (VWF), a blood-clotting protein. When VWF is deficient or abnormal, it causes a common inherited bleeding disorder, von Willebrand disease. VWF is also implicated in arterial and deep-vein thrombosis, stroke, atherosclerosis, sickle cell crisis, and sepsis. Read more »
Dylan McReynolds, Computer Systems Engineer
Dylan McReynolds joined the ALS Computing Program in February. After spending 25 years working in industry, he is excited to meet beamline scientists and users to understand and support their software needs. Read more »
ALS Director Announces Andreas Scholl as New Science Deputy
I am delighted to inform you that our search for a new science deputy has ended successfully with the appointment of ALS senior staff scientist Andreas Scholl. I look forward to working with him as we continue to manage this world-leading facility and get ready for ALS-U science. Read more »
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
PDE4D enzymes are important for normal brain function. Mutations have been asssociated with an ultrarare neurodevelopmental disorder, and genetic variation in PDE4D contributes to biological variation in human cognitive ability. Here, researchers report on novel PDE4D inhibitors providing potent memory-enhancing effects in a mouse model, with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors. Read more »
Chiral Crystals Give Rise to Topological Conductors
Researchers have discovered materials whose chiral crystal structures produce chirality in their electronic behavior. These topological conductors retain their unique electronic properties regardless of defects and open new possibilities in materials research. Read more »
April 2019 Message from the UEC
Fanny Rodolakis, the chair of the Users’ Executive Committee (UEC) for 2019, reports on the most recent UEC meeting and calls for speaker suggestions for this year’s User Meeting. Read more »
Superconductor Exhibits “Glassy” Electronic Phase
Researchers discovered that electrons in a high-temperature superconductor can exhibit a new type of collective behavior that is more “glassy” (disordered) than expected. The study provides valuable insight into the nature of collective electron behaviors and how they relate to high-temperature superconductivity. Read more »
ALS Doctoral Fellowship Applications Open June 1
ALS Doctoral Fellowships in Residence allow early-career researchers to spend a year at the ALS working at the frontier of synchrotron radiation research and helping advance state-of-the-art techniques. Applications will be accepted from June 1–June 30. Read more »
Infrared Light Reveals Microstripes at Insulator-Metal Transition
In this study of a current-driven insulator-to-metal transition, a distinctive stripe pattern develops between the insulating and metallic phases. The work reveals remarkable new features of electrically induced insulator-to-metal transitions in materials with potential applications in energy-efficient memory and transistor devices. Read more »
- « Previous Page
- 1
- …
- 74
- 75
- 76
- 77
- 78
- …
- 131
- Next Page »