A group of researchers studying the world’s most abundant protein, an enzyme involved in photosynthesis called rubisco, showed how evolution can lead to a surprising diversity of molecular assemblies that all accomplish the same task. The findings reveal the possibility that many of the proteins we thought we knew actually exist in other, unknown shapes. Read more »
ALS Work Using Protein Crystallography
Protein crystallography is used for determining the molecular structure of proteins. Crystallized protein molecules cause a beam of incident x-rays to scatter in many directions, with constructive and destructive interference generating a diffraction pattern. By analyzing these patterns, a crystallographer can produce a three-dimensional picture of the density of electrons within the crystal and thus determine the protein's structure.
Deep-Learning AI Program Accurately Predicts Key Rotavirus Protein Fold
Rotaviruses are the major causative agents of gastroenteritis worldwide. Attempts to design vaccines are complicated by the rotaviruses’ enormous genetic and immunological diversity. At the ALS, researchers validated the novel structure of a key rotavirus protein, predicted using AlphaFold2, a deep-learning artificial-intelligence program. Read more »
Molecular Switch Triggers Changes in Plant Structure
Using x-ray crystallography, biochemistry, and plant genetics, researchers identified a molecular switch that triggers modifications to plant structure in response to environmental conditions. A greater understanding of this adaptive process will help scientists optimize plants for efficient nutrient uptake and resistance to parasitic species. Read more »
Bacterial Enzyme Produces Biodegradable Polymer
Researchers discovered a bacterial enzyme that synthesizes a biopolymer whose repeating units are linked together in way that had not been previously observed. The new polymer is biodegradable and may be biocompatible, with potential for applications ranging from medical therapeutics to eco-friendly plastic alternatives. Read more »
Newly Discovered Bacterial Enzyme Produces Useful Biopolymer
Researchers identified a bacterial enzyme that produces a novel biopolymer. The polymer, dubbed acholetin, is a chain of sugar molecules known as a polysaccharide. Acholetin is similar in structure to chitin, the major component of insect exoskeletons, and holds promise as a useful biomaterial because of its biodegradability and biocompatibility. Read more »
Molecular Hijacking of a MicroRNA by the Hepatitis C Virus
The hepatitis C virus (HCV), which attacks the liver, is known to repurpose host-cell components known as microRNAs—short RNA strands that act to silence gene expression. Now, the molecular structure of an HCV site bound to a microRNA complex revealed how their interactions shield the virus from the host cell’s protective response. Read more »
Programmable stiffness and stress–relaxation of cross-linked self-assembling peptide hydrogels
An AFM image representing a supramolecular hydrogel based on a cross-linked self-assembling peptide (SAP). Cross-linking allows for precise tuning of biomechanical properties, spanning the range of stiffness values found in the human central nervous system, pancreas, liver, lung, and skin tissues. The findings provide a new strategy helpful for soft tissue regeneration. Read more »
DNA Synthesis: Flip It and Reverse It
What if the current model for DNA synthesis were flipped on its head? Using time-resolved x-ray crystallography, researchers gained new insights into this essential biological process, revealing that two steps in the synthesis pathway are, in reality, reversed. Read more »
An Antibody That Broadly Neutralizes SARS-CoV-2
An antibody that appears to neutralize all known SARS-CoV-2 strains and closely related coronaviruses was discovered with the help of the ALS. The work highlights principles underlying antibody potency, breadth, and escapability that can guide the development of therapeutics against the current and potential future pandemics. Read more »
Sounding the Antiviral Alarm: A New Family of Immune-System Sensors
Comparison of enzyme structures from humans and insects revealed a new family of evolutionarily related immune-system sensors, triggered by viral RNA or DNA to produce tailored signals that initiate antiviral action. The results shed new light on the diversity and development of immune defenses in animals. Read more »
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