The study reports the first structure of human EPG5 (HsEPG5) determined by cryo-EM and AlphaFold2 modeling. Read more »
ALS Work Using Scattering/Diffraction
These techniques make use of the patterns of light produced when x-rays are deflected by the closely spaced lattice of atoms in solids and are commonly used to determine the structures of crystals and large molecules such as proteins.
Native American Interns Explore Engineering Opportunities at the Lab
This last summer, Berkeley Lab hosted three students from Navajo Technical University in a DOE-funded initiative that partners national labs with learning institutions whose populations are historically underrepresented in science. The goal is to increase enrollment of Native American students in Navajo Tech engineering programs. Read more »
A Macromolecular Scaffold for Probing Actinium Chemistry
By encapsulating actinium atoms within a macromolecular complex for analysis using protein crystallography, researchers discovered that actinium has a unique solid-state bonding configuration. A better understanding of actinium behavior could help improve a promising cancer treatment known as targeted alpha therapy. Read more »
Local Chemical Enhancement and Gating of Organic Coordinated Ionic-Electronic Transport
Record ion mobility and conductivities are revealed within a nanoscopic interfacial superhighway of an organic mixed ionic-electronic conductor. Fast ion transport can be controlled by hydrophobicity of molecules local to this channel, effectively gating ion access to the superhighway. This mechanism is used in a novel chemical sensing device which detects the dynamics of a local, buried chemical reaction. Read more »
Advancing high-temperature electrostatic energy storage via linker engineering of metal–organic frameworks in polymer nanocomposites
High-performance, thermally resilient polymer dielectrics are essential for film capacitors used in advanced electronic devices and renewable energy systems, particularly at elevated temperatures where conventional polymers fail to perform. Herein, we unravel the untapped potential of UiO-66 metal–organic framework (MOF) derivatives as exceptional nanofillers for tuning the properties of the widely used polyetherimide (PEI). Read more »
Jamming Giant Molecules at Interface in Organic Photovoltaics to Improve Performance and Stability
Giant molecule acceptors (GMAs), known for their large size and intricate functional structures, are an emerging focus in materials science. Through implementation of an interface-enhanced layer-by-layer fabrication strategy, we have successfully demonstrated that GMA with designed electronic structure at interfaces can effectively improve OPV device performance. Read more »
Magnetization Switching in Highly Magnetostrictive Microstructures
Researchers learned how the size, shape, and orientation of microstructures affect how they switch magnetization directions in response to an applied voltage. The work advances our understanding of strain-responsive composite materials for use in energy-efficient electronic applications such as memory devices, sensors, and actuators. Read more »
Protein Pioneer: Enabling Scientists to Design Novel Proteins for the Future
The 2024 Nobel Prize in Chemistry was awarded to David Baker, Demis Hassabis, and John M. Jumper for the development of protein structure prediction and design. At the ALS, Baker leveraged high-throughput small-angle x-ray scattering (SAXS) and protein crystallography capabilities to design novel proteins and pave a new pathway for science, technology, and the environment. Read more »
Manganese Cathodes Could Boost Lithium-ion Batteries
Rechargeable lithium-ion batteries are used in mobile devices, electric vehicles, and energy storage systems. But supplies of nickel and cobalt, commonly used in the cathodes of these batteries, are limited. New research opens up a potential low-cost, safe alternative in manganese, the fifth most abundant metal in the Earth’s crust. Read more »
A Promising Compound for Reversible Male Contraception
Researchers found that a small-molecule protein inhibitor—screened from billions of compounds and analyzed using structural insights from protein crystallography—reversibly suppresses male fertility in mice. The work addresses the pressing need for more contraceptive options that enable all individuals to control their own fertility. Read more »
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