A time-resolved diffraction study conducted at the ALS revealed mechanistic insight into a multi-step chemical reaction for the economical production of aluminum–cerium alloy, a high-performance material with superior temperature stability. The results provide crucial information for the application of the method on an industrial scale. Read more »
ALS Work Using Scattering/Diffraction
These techniques make use of the patterns of light produced when x-rays are deflected by the closely spaced lattice of atoms in solids and are commonly used to determine the structures of crystals and large molecules such as proteins.
Strategic ALS Projects Reach Key Milestones
Thanks to the hard work and dedication of multidisciplinary teams from groups across the ALS, a spate of important milestones occurred over the past month, for projects involving the new QERLIN beamline, the MERLIN beamline upgrade, and a new chamber for computer-chip metrology in Sector 12. Read more »
Converting N2 into Usable Form under Ambient Conditions
Researchers learned how molecular structure relates to function in catalysts that convert atmospheric nitrogen into more usable forms at room temperature and pressure. The work could lead to greater energy efficiency in producing nitrogen-based products such as fertilizer where large-scale industrial processes are unfeasible. Read more » 
Caught in the Actinium
In this work, researchers demonstrated a macromolecular scaffold that combines an 8-coordinate synthetic ligand and a mammalian protein to characterize the solution and solid-state behavior of the longest-lived actinium isotope. The information could help design better cancer treatments. Read more »
Engineered π⋯π interactions favour supramolecular dimers X@[FeL3]2(X = Cl, Br, I): solid state and solution structure
Intermolecular interactions drive the formation of biological supramolecular architectures, inspiring the design of artificial supramolecular assemblies and molecular machines. Here, the engineering of supramolecular interactions allows selection of a self-recognition process of dimerization over one of helicate-cage formation. Read more »
Double-Helical Tiled Chain Structure of the Twist-Bend Liquid Crystal Phase in CB7CB
The structure of the twist-bend (TB) phase of the bent dimer CB7CB and its mixtures with 5CB is characterized, revealing a hidden invariance of the self-assembly of the TB structure. Remarkably, the distance along the length for a single turn of this helix is given by 2πRmol, where Rmol is the radius of the bend curvature of a single all-trans CB7CB molecule. Read more »
Time-Resolved SAXS Screen of Small-Molecule Drug Candidates
Time-resolved, high-throughput, small-angle x-ray scattering improved the screening of small-molecule drug candidates, providing insight into how they stimulate structural transitions in protein targets. The work will speed the discovery of treatments designed to activate biomolecular dynamics associated with desired therapeutic outcomes. Read more »
Mechanistic Insight into a Viral-Factory Component
Recent protein-structure studies conducted at the ALS provided mechanistic insights into the function of a protein (σNS) involved in viral replication. Understanding these mechanisms will foster the development of therapeutic strategies against viruses that use σNS-like proteins to replicate. Read more »
Engineering Lipophilic Aggregation of Adapalene and Adamantane-Based Cocrystals via van der Waals Forces and Hydrogen Bonding
Adamantanes are emerging building blocks for active pharmaceutical ingredients. In this work, we sought to understand how systematic modification of the hydrophobic cage in adamantanes could result in changes to crystal packing in single and multicomponent organic solids. Read more »
Superhard Materials at the Nanoscale: Smaller is Better
In the superhard material, rhenium diboride, smaller grain size leads to greater yield strength (i.e., the amount of stress tolerated before permanent deformation). Because such transition-metal borides are extremely hard, metallic, and can be synthesized at ambient pressure, they have exciting potential for use in next-generation cutting tools. Read more »
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