ALS researchers, in collaboration with software and nanofabrication small businesses, developed a way to improve the accuracy of instruments that measure the surfaces of x-ray mirrors. The work significantly improves the quality of the data needed for the fabrication and optimal performance of advanced x-ray beamlines and space telescopes. Read more »
Industry@ALS
Experimental Drug Targets HIV in a Novel Way
Researchers from Gilead Sciences Inc. solved the structure of an experimental HIV drug bound to a novel target: the capsid protein that forms a shield around the viral RNA. The work could lead to a long-lasting HIV treatment that overcomes the problem of drug resistance and avoids the need for burdensome daily pill-taking. Read more »
Characterization of EUV Optics using Intrinsic Mask Roughness
Researchers developed an in situ computational technique for measuring aberrations in EUV optics, taking advantage of the surface roughness of photomasks used to transfer circuit patterns onto chips. The technique will prove increasingly valuable in the characterization of coherent light sources and beamline optical systems. Read more »
The Flat Band in Magic-Angle Graphene Visualized
Researchers visualized flat band structures associated with exotic electronic phases in stacked graphene layers offset from each other by a “magic angle.” The work corroborates theoretical predictions and has significant implications for phenomena of technological and fundamental interest, such as topological phases and superconductivity. Read more »
On-Off Switch for Regulating Tumor-Cell Growth
The mechanisms that affect the regulation of cell growth in certain tumor cells were revealed by a Genentech study of enzyme structures, conducted in part at the ALS. The work establishes a framework for the rational discovery of new therapeutics to improve upon currently existing treatments for certain cancers. Read more »
How a Cancer Drug Targets Proteins for Degradation
Protein structures obtained by Novartis researchers helped reveal how a cancer drug promotes the degradation of proteins essential to cell proliferation. A detailed understanding of the drug’s mechanism of action is key to determining whether the protein-degradation system can be reprogrammed to degrade different targets. Read more »
A Scalable Platform for Two-Dimensional Metals
Using a new method for stabilizing a two-dimensional (2D) metal on a large-area platform, researchers probed the origins of the material’s superconductivity. The work represents a notable milestone in advancing 2D materials toward broad applications in topological computing, advanced optics, and molecular sensing. Read more »
A Graphene Innovation That Is Music to Your Ears
A California-based company called GraphAudio is moving toward commercializing graphene-based audio technology developed by researchers at Berkeley Lab and UC Berkeley. The technology could transform a variety of devices, including speakers, earbuds and headphones, microphones, autonomous vehicle sensors, and ultrasonic and echolocation systems. Read more »
Water Improves Material’s Ability to Capture CO2
With the help of the ALS, researchers from UC Berkeley and ExxonMobil fine-tuned a material to capture CO2 in the presence of water. The parties have applied for a patent on the material, which was developed for use on the relatively humid flue gases emitted by certain natural gas power plants, a cleaner-burning alternative to coal. Read more » 
ALS Reveals Vulnerability in Cancer-Causing Protein
A promising anticancer drug, AMG 510, was developed by Amgen Inc. with the help of novel structural insights gained from protein structures solved at the ALS. AMG 510, which is currently in phase II clinical trials for efficacy, targets tumors caused by mutations in the KRAS protein, one of the most common causes of cancer. Read more »
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