A collaboration of university and industry researchers used x-ray crystallography to investigate how the chikungunya virus, which can cause debilitating joint pain, engages a receptor protein found on the surfaces of joint cells. The work provides a path forward in the fight against a family of viruses that can result in acute and chronic arthritis. Read more »
Industry@ALS
Unique Cancer Drug Discovered With Help From Advanced Light Source Begins Historic Clinical Trial
Errors in the KRAS gene, which encodes a crucial cell-signaling protein, are one of the most common causes of cancer. Seeking to develop a long-sought direct inhibitor, researchers at Amgen conducted x-ray crystallography of KRAS(G12C) proteins at the ALS. The high-resolution structural maps helped Amgen make the breakthrough discovery of a small pocket on the molecule. Read more »
Multimodal Study of Ion-Conducting Membranes
Using multiple x-ray characterization tools, researchers showed how chemical and structural changes improve the performance of a novel ion-conducting polymer (ionomer) membrane from 3M Company. The work provides insight into factors impacting the proton conductivity of ionomers used for fuel cells and the production of hydrogen fuel. Read more »
ALS Confirms Mechanism for Improved Fuel Cell Catalysis
Aided by x-ray absorption spectroscopy at the ALS, researchers from Toyota and the University of Akron have uncovered a new catalysis mechanism to improve oxidation-reduction reactions in certain fuel cells by 40%. This enhancement, based on tin oxide, will support efforts to increase fuel efficiency in electric vehicles. Read more »
Team Chemistry Powers Industry Collaborations at the ALS
At the ALS, industry users find scientific experts and specialized facilities. Their collaboration drives discovery in a variety of fields, yielding results that are greater than the sum of their parts. Read more »
Memristor Collaboration between ALS and Hewlett Packard Labs Propels Theory to Application
The development of an idea into a commercial product can take decades, a timeframe that allows contributions from multiple generations of scientists and requires investment in basic research. Collaborative research between the ALS and Hewlett Packard Labs has advanced the memristor, a device that can store information using little to no power. Read more »
TE Connectivity Uses ALS to Improve Conductive Plastics
TE Connectivity used ALS microtomography capabilities to optimize the material and manufacturing parameters of their conductive plastics to impart good electrical conductivity. Conductive plastics with good electrical properties offer processing and cost benefits over metal alternatives, with applications ranging from automotive to data communications. Read more »
Genentech Advances Research Toward Better Medicines to Lower Cholesterol
Genentech has been working in collaboration with the ALS for years with the goal of identifying a better cholesterol treatment mechanism that targets a cholesterol-regulating protein in the body known as PCSK9. Recent advances in understanding PCSK9’s structure have put them closer to that goal. Read more »
PepsiCo Explores Future Food Products at the ALS
Global food and beverage giant PepsiCo has been using ALS tomography beamline 8.3.2 to understand more about the chemical structure and behavior of their starch-based snack foods, with the goal of creating a whole new category of snacks that consumers cook at home in their own microwaves. Read more »
Global Blood Therapeutics Uses ALS to Tackle Sickle Cell Disease
Sickle cell disease (SCD), which affects millions of people worldwide, has traditionally been treated with a cytotoxic drug that has a range of negative side effects and variable patient response. Bay Area biopharmaceutical company Global Blood Therapeutics (GBT) is on a mission to develop a better treatment and is using the ALS to help. Read more »
