Malfunctions in the complex protein “machinery” of serotonin transport can result in depression, obsessive-compulsive disorder, aggression, anxiety, and Parkinson’s disease. Now, researchers have obtained x-ray crystallographic structures of the difficult-to-crystallize human serotonin transporter bound to two commonly prescribed antidepressant drug molecules. Read more »
Mapping the Topology of the Human Genome
To determine how a gene will function, we need to know the spatial arrangement of the genome in the nucleus. Researchers have made a significant advance in determining this 3D organization by combining modeling and probabilistic calculations with minimally perturbing imaging techniques. Read more »
Understanding the Key to Henipavirus Infection
The Hendra virus was the first member of the genus Henipavirus, an emergent group of viruses with a high mortality rate. Knowledge of the protein structure that mediates Hendra entry into host cells could enable the design of antigens with improved immunogenic response. Read more »
Power-Amplified Predatory Strikes in Trap-Jaw Spiders
Using a combination of high-speed video, molecular phylogenetic analysis, and x-ray microtomography of a family of tiny trap-jaw spiders, researchers discovered that power-amplified predatory strikes evolved four times independently, once the basic trap-jaw body plan was in place. Read more »
Reducing Plant Lignin for Cheaper Biofuels
Scientists have identified and validated a novel approach to reducing lignin in plants by tweaking a key lignin enzyme. Their technique could help lower the cost of converting biomass into carbon-neutral fuels to power cars and other sustainably developed bio-products. Read more »
Shutting Out Ebola and Other Viruses
Researchers have used protein crystallography at the ALS to understand how a drug molecule that has shown some efficacy against Ebola in mice inactivates a membrane protein, called TPC1, used by viruses to infect host cells. Read more »
Exploring the Repeat-Protein Universe
Researchers have published a landmark study that used both crystallography and SAXS to validate computationally designed structures of novel proteins with repeated motifs. The results show that the protein-folding universe is far larger than realized, opening up a wide array of new possibilities for biomolecular engineering. Read more »
Improving Anti-Influenza Medications
Protein crystallography at ALS Beamline 8.3.1 helped scientists understand the M2 proton-channel structure from the influenza A virus, an understanding that is needed to design better anti-influenza medications. Read more »
Improving Meningococcal Vaccines
Scientists have found a way to improve the stability of an essential antigenic protein to develop vaccines with higher efficacy for prevention of bacterial meningitis. Read more »
New Hope for Retinitis Pigmentosa Patients
Using FTIR microspectroscopy at the NSLS in Brookhaven and at ALS Beamline 1.4.3, scientists got a first glimpse into the structural changes that result from point mutations in opsin, one of the causes of retinitis pigmentosa. Read more »
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