A time-resolved study using infrared spectromicroscopy in a carefully controlled environment revealed why enzymes get bogged down when trying to break up cellulose from plants. The work sheds new light on the challenge of extracting the sugars locked up in plants for use in making petroleum-free fuels, chemicals, and medicines. Read more »
Watching the Enzymes that Convert Plant Fiber into Simple Sugars
Research from Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory, and UC Davis sheds new light on how to access the sugars locked up in plants to produce petroleum-free fuels, chemicals, and medicines. The technique used combines a novel microfluidic device and infrared spectroscopy to study how a cellulose-degrading enzyme works in real time. Read more »
Computer-Aided Protein Design for New Biomaterials
Using a computer-based approach, researchers designed porous protein crystals that were revealed to be stable, tunable, and atomically accurate using x-ray scattering and diffraction at the ALS. The work provides a powerful new platform for biological materials engineering and opens up wide applications in biotechnology and medicine. Read more »
How Structure Affects the Activity of Lipid Nanoparticles
Berkeley Lab and Genentech scientists related the internal structures of lipid nanoparticles to their efficacy at drug delivery, using a combination of methods including x-ray scattering at the ALS. The work promises to expedite the development of drug delivery systems for the treatment of diseases such as COVID-19 and cancer. Read more »
A New Pathway for Clearing Misfolded Proteins
Researchers integrated several approaches, such as cryogenic 3D imaging at the ALS, to define a novel cellular pathway—involving a shared “garbage dump”—for clearing misfolded proteins from cells. The pathway is a potential therapy target for age-related diseases like Alzheimer’s, Huntington’s, and Parkinson’s diseases. Read more »
Breaking Barriers in Drug Delivery with Better Lipid Nanoparticles
A collaboration between Berkeley Lab and Genentech, a member of the Roche Group, is working to break through some of the drug delivery bottlenecks by designing the most effective lipid nanoparticles (LNPs)—tiny spherical pouches made of fatty molecules that encapsulate therapeutic agents until they dock with cell membranes and release their contents. Read more »
Plant Enzyme Builds Polymers That Fortify Cell Walls
With data obtained at the ALS, researchers gained insight into how an enzyme orchestrates the synthesis of a pectin polymer that imparts strength and flexibility to plant cell walls. The work could lead to improved biofuel production and guide the design of polymers with tailored functionalities for industrial or biomedical applications. Read more »
Gemini Beamline 2.0.1 Banks Its First Protein Structure
A protein structure obtained from ALS Beamline 2.0.1 (“Gemini”) has recently been published in the literature and deposited into the Protein Data Bank (PDB)—two significant firsts for this beamline. The structure helped provide new insights into the molecular mechanisms involved in triggering certain inflammatory diseases. Read more »
Chatbot-Style AI Designs Novel Functional Protein
Researchers used an artificial intelligence (AI) algorithm, similar to those used in natural-language (“chatbot”) models, to design a functional protein that was then structurally validated at the ALS. The work could speed the development of novel proteins for almost anything from therapeutics to degrading plastic. Read more »
Protein Assemblies Show Surprising Variability
Protein-structure studies performed in part at the ALS helped researchers discover that the protein assemblies in a key carbon-cycling enzyme can rearrange with surprising ease. The findings raise the prospect of genetically tuning the protein in agricultural plant species to produce more productive and resource-efficient crops. Read more »
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