By locking down certain movable parts of a modular drug-building protein, researchers learned new details about how carrier proteins transfer the product protein between modules. The results offer insights that could enable scientists to design and create new and improved medicines, such as antibiotics, using synthetic biology. Read more »
Mapping the Quantum Landscape of Electrons in Solids
Researchers found a way to reconstruct quantum geometric tensors (QGTs)—mathematical entities that encode how an electron’s wave function is shaped by its quantum environment. The mapping of QGTs enables the discovery and control of novel quantum phenomena such as superconductivity and unconventional electronic phases. Read more » 
Bennu’s Ancient Brine Sheds Light on Recipe for Life
Researchers traced the evolution of minerals (“salts”) in an ancient brine, as recorded in samples from the asteroid Bennu, returned to Earth by NASA’s OSIRIS-REx mission. The results support the idea that asteroids like Bennu may have delivered water and essential chemical building blocks of life to Earth in the distant past. Read more »
Identification and Structural Characterization of Antibodies for Severe Malaria
Researchers used x-ray crystallography at the ALS to characterize how two newly discovered antibodies prevent the protein interactions responsible for severe malaria. Understanding this mechanism offers novel insights for vaccine development. Read more »
A Macromolecular Scaffold for Probing Actinium Chemistry
By encapsulating actinium atoms within a macromolecular complex for analysis using protein crystallography, researchers discovered that actinium has a unique solid-state bonding configuration. A better understanding of actinium behavior could help improve a promising cancer treatment known as targeted alpha therapy. Read more »
Lattice-Dependent Spin Textures in High-Tc Superconductors
Researchers found that in bismuth-based cuprate superconductors, charge imbalances caused by lattice distortions generate persistent and universal patterns of spin polarization. The results supply a previously missing but essential ingredient in efforts to understand the mechanisms driving the electronic behavior of high-temperature superconductors. Read more »
Magnetization Switching in Highly Magnetostrictive Microstructures
Researchers learned how the size, shape, and orientation of microstructures affect how they switch magnetization directions in response to an applied voltage. The work advances our understanding of strain-responsive composite materials for use in energy-efficient electronic applications such as memory devices, sensors, and actuators. Read more »
Studying Interfacial Effects in Solid-Electrolyte Batteries
An ambient-pressure probe of a solid electrolyte revealed how surface electrochemical mechanisms lead to poor electrolyte performance and battery failure. The results can help scientists engineer better coatings and interfaces, which are essential for building safer and better-performing batteries, particularly for use in vehicles. Read more »
Protein Pioneer: Enabling Scientists to Design Novel Proteins for the Future
The 2024 Nobel Prize in Chemistry was awarded to David Baker, Demis Hassabis, and John M. Jumper for the development of protein structure prediction and design. At the ALS, Baker leveraged high-throughput small-angle x-ray scattering (SAXS) and protein crystallography capabilities to design novel proteins and pave a new pathway for science, technology, and the environment. Read more »
A New Way to “Squeeze” Infrared Wavelengths Down to Size
Researchers demonstrated a new way to confine, or “squeeze,” infrared light by coupling photons with phonons (lattice vibrations) within a certain type of thin film. The work heralds a new class of optical materials for controlling infrared light, with potential applications in photonics, sensors, and microelectronic heat management. Read more »
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